CASP12
Gene Ontology Biological Process
- apoptotic process [IDA]
- endoplasmic reticulum unfolded protein response [IDA]
- intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress [IGI, TAS]
- positive regulation of apoptotic process [ISO]
- positive regulation of cysteine-type endopeptidase activity involved in apoptotic process [ISO]
- protein autoprocessing [ISO]
- proteolysis [IBA, ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
PDCD6
Gene Ontology Biological Process
- activation of cysteine-type endopeptidase activity involved in apoptotic process [IDA]
- apoptotic process [IDA]
- cellular response to heat [ISO]
- intracellular protein transport [ISO]
- negative regulation of TOR signaling [ISO]
- negative regulation of protein kinase B signaling [ISO]
- negative regulation of vascular endothelial growth factor receptor signaling pathway [ISO]
- positive regulation of angiogenesis [ISO]
- positive regulation of cysteine-type endopeptidase activity involved in apoptotic process [ISO]
- positive regulation of endothelial cell migration [ISO]
- positive regulation of endothelial cell proliferation [ISO]
- proteolysis [IBA]
- response to calcium ion [IDA]
- vascular endothelial growth factor receptor-2 signaling pathway [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Molecular components of a cell death pathway activated by endoplasmic reticulum stress.
Alterations in Ca2+ homeostasis and accumulation of misfolded proteins in the endoplasmic reticulum (ER) cause ER stress that ultimately leads to programmed cell death. Recent studies have shown that ER stress triggers programmed cell death via an alternative intrinsic pathway of apoptosis that, unlike the intrinsic pathway described previously, is independent of Apaf-1 and cytochrome c. In the present work, ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID