NEDD4
Gene Ontology Biological Process
- T cell activation [ISO]
- adaptive immune response [ISO]
- blood vessel morphogenesis [ISO]
- cellular response to UV [ISO]
- development involved in symbiotic interaction [ISO]
- endocardial cushion development [ISO]
- glucocorticoid receptor signaling pathway [ISO]
- immune response [IEP]
- lysosomal transport [ISO]
- negative regulation of sodium ion transport [ISO]
- negative regulation of transcription from RNA polymerase II promoter [ISO]
- negative regulation of transcription from RNA polymerase II promoter in response to UV-induced DNA damage [ISO]
- negative regulation of vascular endothelial growth factor receptor signaling pathway [ISO, ISS]
- neuromuscular junction development [ISO]
- neuron projection development [ISO]
- outflow tract morphogenesis [ISO]
- positive regulation of nucleocytoplasmic transport [ISO]
- positive regulation of phosphatidylinositol 3-kinase signaling [ISO]
- positive regulation of protein catabolic process [ISO]
- progesterone receptor signaling pathway [ISO]
- protein K63-linked ubiquitination [IDA]
- protein monoubiquitination [ISO]
- protein targeting to lysosome [ISO]
- protein ubiquitination [ISO, ISS]
- protein ubiquitination involved in ubiquitin-dependent protein catabolic process [IBA, ISO]
- receptor catabolic process [ISO]
- receptor internalization [ISO]
- regulation of dendrite morphogenesis [IDA, ISO]
- regulation of ion transmembrane transport [ISO]
- regulation of membrane potential [ISO]
- regulation of potassium ion transmembrane transporter activity [ISO]
- regulation of synapse organization [ISO]
- response to denervation involved in regulation of muscle adaptation [IEP]
- transmission of virus [ISO]
- ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway [ISO]
Gene Ontology Molecular Function- RNA polymerase binding [ISO]
- beta-2 adrenergic receptor binding [ISO]
- phosphoserine binding [ISO]
- phosphothreonine binding [ISO]
- proline-rich region binding [ISO]
- protein C-terminus binding [IDA, IPI]
- protein binding [IPI]
- protein domain specific binding [ISO]
- sodium channel inhibitor activity [ISO]
- ubiquitin binding [ISO]
- ubiquitin protein ligase activity [ISO]
- ubiquitin-protein transferase activity [IDA, ISO]
- RNA polymerase binding [ISO]
- beta-2 adrenergic receptor binding [ISO]
- phosphoserine binding [ISO]
- phosphothreonine binding [ISO]
- proline-rich region binding [ISO]
- protein C-terminus binding [IDA, IPI]
- protein binding [IPI]
- protein domain specific binding [ISO]
- sodium channel inhibitor activity [ISO]
- ubiquitin binding [ISO]
- ubiquitin protein ligase activity [ISO]
- ubiquitin-protein transferase activity [IDA, ISO]
Gene Ontology Cellular Component
SCNN1B
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Reconstituted Complex
An interaction is inferred between proteins in vitro. This can include proteins in recombinant form or proteins isolated directly from cells with recombinant or purified bait. For example, GST pull-down assays where a GST-tagged protein is first isolated and then used to fish interactors from cell lysates are considered reconstituted complexes (e.g. PUBMED: 14657240, Fig. 4A or PUBMED: 14761940, Fig. 5). This can also include gel-shifts, surface plasmon resonance, isothermal titration calorimetry (ITC) and bio-layer interferometry (BLI) experiments. The bait-hit directionality may not be clear for 2 interacting proteins. In these cases the directionality is up to the discretion of the curator.
Publication
Affinity and specificity of interactions between Nedd4 isoforms and the epithelial Na+ channel.
The epithelial Na+ channel (alphabetagammaENaC) regulates salt and fluid homeostasis and blood pressure. Each ENaC subunit contains a PY motif (PPXY) that binds to the WW domains of Nedd4, a Hect family ubiquitin ligase containing 3-4 WW domains and usually a C2 domain. It has been proposed that Nedd4-2, but not Nedd4-1, isoforms can bind to and suppress ENaC activity. ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| NEDD4 SCNN1B | Co-crystal Structure Co-crystal Structure Interaction directly demonstrated at the atomic level by X-ray crystallography. Also used for NMR or Electron Microscopy (EM) structures. If there is no obvious bait-hit directionality to the interaction involving 3 or more proteins, then the co-crystallized proteins should be listed as a complex. | Low | - | BioGRID | 728034 | |
| SCNN1B NEDD4 | Reconstituted Complex Reconstituted Complex An interaction is inferred between proteins in vitro. This can include proteins in recombinant form or proteins isolated directly from cells with recombinant or purified bait. For example, GST pull-down assays where a GST-tagged protein is first isolated and then used to fish interactors from cell lysates are considered reconstituted complexes (e.g. PUBMED: 14657240, Fig. 4A or PUBMED: 14761940, Fig. 5). This can also include gel-shifts, surface plasmon resonance, isothermal titration calorimetry (ITC) and bio-layer interferometry (BLI) experiments. The bait-hit directionality may not be clear for 2 interacting proteins. In these cases the directionality is up to the discretion of the curator. | Low | - | BioGRID | - | |
| SCNN1B NEDD4 | Two-hybrid Two-hybrid Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation. | Low | - | BioGRID | - |
Curated By
- BioGRID