SLC12A2
Gene Ontology Biological Process
- ammonium transmembrane transport [ISO]
- ammonium transport [ISO]
- branching involved in mammary gland duct morphogenesis [IMP]
- chloride transmembrane transport [ISO]
- chloride transport [ISO]
- detection of mechanical stimulus involved in sensory perception of sound [IMP]
- hyperosmotic response [ISO]
- mammary duct terminal end bud growth [IMP]
- multicellular organism growth [IMP]
- organic cation transport [ISO]
- positive regulation of cell volume [ISO]
- potassium ion transport [ISO]
- sodium ion transport [ISO]
- transepithelial ammonium transport [ISO]
- transepithelial chloride transport [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
STK39
Gene Ontology Biological Process
- intracellular signal transduction [IBA, ISO]
- negative regulation of potassium ion transmembrane transport [IDA, ISO]
- negative regulation of potassium ion transmembrane transporter activity [ISO]
- negative regulation of protein phosphorylation [IDA]
- negative regulation of rubidium ion transmembrane transporter activity [ISO]
- negative regulation of rubidium ion transport [ISO]
- peptidyl-serine phosphorylation [ISO]
- peptidyl-threonine phosphorylation [ISO]
- positive regulation of potassium ion transport [ISO]
- protein phosphorylation [IBA, ISO]
- regulation of blood pressure [IMP]
- regulation of inflammatory response [IDA]
- regulation of ion homeostasis [IMP]
- signal transduction by phosphorylation [IBA, ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Cation chloride cotransporters interact with the stress-related kinases Ste20-related proline-alanine-rich kinase (SPAK) and oxidative stress response 1 (OSR1).
Cells respond to stress stimuli by mounting specific responses. During osmotic and oxidative stress, cation chloride cotransporters, e.g. Na-K-2Cl and K-Cl cotransporters, are activated to maintain fluid/ion homeostasis. Here we report the interaction of the stress-related serine-threonine kinases Ste20-related proline-alanine-rich kinase (SPAK) and oxidative stress response 1 (OSR1) with the cotransporters KCC3, NKCC1, and NKCC2 but not KCC1 and KCC4. ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID