STX4A
Gene Ontology Biological Process
- SNARE complex assembly [IDA]
- intracellular protein transport [IBA]
- long-term synaptic potentiation [ISO]
- membrane fusion [ISO]
- organelle fusion [ISO]
- positive regulation of catalytic activity [ISO]
- positive regulation of cell adhesion [ISO]
- positive regulation of cell migration [ISO]
- positive regulation of cell proliferation [ISO]
- positive regulation of chemotaxis [ISO]
- positive regulation of eosinophil degranulation [ISO]
- positive regulation of establishment of protein localization to plasma membrane [ISO]
- positive regulation of immunoglobulin secretion [ISO]
- positive regulation of insulin secretion involved in cellular response to glucose stimulus [ISO]
- positive regulation of protein localization to cell surface [ISO]
- positive regulation of protein localization to plasma membrane [ISO]
- protein complex assembly [ISO]
- regulation of exocytosis [ISO]
- regulation of extrinsic apoptotic signaling pathway via death domain receptors [ISO]
- response to hydroperoxide [ISO]
- synaptic vesicle docking [ISO]
- synaptic vesicle exocytosis [TAS]
- synaptic vesicle fusion to presynaptic membrane [IBA]
- vesicle docking [IBA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- SNARE complex [IBA, ISO]
- apical plasma membrane [ISO]
- basolateral plasma membrane [IDA, ISO]
- cell [TAS]
- cell surface [IDA, ISO]
- cytoplasm [IDA]
- dendritic spine [ISO]
- endosome [ISO]
- extracellular space [ISO]
- extracellular vesicular exosome [ISO]
- integral component of membrane [IBA]
- intracellular [ISO]
- lamellipodium [ISO]
- lateral loop [IDA]
- membrane [ISO]
- myelin sheath adaxonal region [IDA]
- perinuclear region of cytoplasm [IDA]
- plasma membrane [IDA, ISO]
- sarcolemma [ISO]
- somatodendritic compartment [ISO]
- specific granule [ISO]
- synapse [ISO]
- synaptic vesicle [IBA]
- trans-Golgi network [IDA]
STXBP4
Gene Ontology Biological Process
- cellular response to DNA damage stimulus [ISO]
- glucose transport [IDA]
- insulin receptor signaling pathway [IDA]
- positive regulation of cell cycle G1/S phase transition [ISO]
- positive regulation of keratinocyte proliferation [ISO]
- protein stabilization [ISO]
- protein targeting [IDA]
- regulation of insulin secretion involved in cellular response to glucose stimulus [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Synip: a novel insulin-regulated syntaxin 4-binding protein mediating GLUT4 translocation in adipocytes.
Insulin-stimulated glucose transport and GLUT4 translocation require regulated interactions between the v-SNARE, VAMP2, and the t-SNARE, syntaxin 4. We have isolated a novel syntaxin 4-binding protein, Synip, which specifically interacts with syntaxin 4. Insulin induces a dissociation of the Synip:syntaxin 4 complex due to an apparent decrease in the binding affinity of Synip for syntaxin 4. In contrast, the carboxyterminal ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| STXBP4 STX4A | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - |
Curated By
- BioGRID