BAIT
BCL2
AW986256, Bcl-2, C430015F12Rik, D630044D05Rik, D830018M01Rik
B cell leukemia/lymphoma 2
GO Process (135)
GO Function (13)
GO Component (14)
Gene Ontology Biological Process
- B cell differentiation [IMP]
- B cell homeostasis [IMP]
- B cell lineage commitment [IMP]
- B cell proliferation [ISO]
- B cell receptor signaling pathway [ISO]
- CD8-positive, alpha-beta T cell lineage commitment [IMP]
- T cell differentiation [IMP]
- T cell differentiation in thymus [IMP]
- T cell homeostasis [IGI, IMP]
- T cell lineage commitment [IMP]
- actin filament organization [IMP]
- apoptotic mitochondrial changes [IDA]
- apoptotic process [IMP, ISO]
- axon regeneration [IDA]
- axonogenesis [IMP]
- behavioral fear response [IMP]
- branching involved in ureteric bud morphogenesis [IDA, IGI]
- cell aging [IMP]
- cell growth [IMP]
- cell morphogenesis [IMP]
- cell proliferation [IGI]
- cellular calcium ion homeostasis [IDA]
- cellular response to DNA damage stimulus [ISO]
- cellular response to glucose starvation [IDA]
- cellular response to hypoxia [IDA]
- cellular response to organic substance [IDA]
- cochlear nucleus development [IMP]
- defense response to virus [ISO]
- developmental growth [IMP]
- developmental pigmentation [IGI, IMP]
- digestive tract morphogenesis [IMP]
- ear development [IGI, IMP]
- endoplasmic reticulum calcium ion homeostasis [IGI]
- extrinsic apoptotic signaling pathway in absence of ligand [IGI]
- extrinsic apoptotic signaling pathway via death domain receptors [ISO]
- focal adhesion assembly [IMP]
- gland morphogenesis [IMP]
- glomerulus development [IMP]
- growth [IMP]
- hair follicle morphogenesis [IMP]
- hemopoiesis [IMP]
- homeostasis of number of cells within a tissue [IMP]
- immune system development [IMP]
- intrinsic apoptotic signaling pathway in response to DNA damage [IBA]
- intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress [ISS]
- intrinsic apoptotic signaling pathway in response to oxidative stress [IMP]
- kidney development [IGI, IMP]
- leukocyte homeostasis [IMP]
- lymphocyte homeostasis [IGI, IMP]
- lymphoid progenitor cell differentiation [IMP]
- male gonad development [IGI]
- melanin metabolic process [IMP]
- melanocyte differentiation [IGI, IMP]
- mesenchymal cell development [IMP]
- metanephros development [IMP]
- negative regulation of G1/S transition of mitotic cell cycle [IDA, IMP]
- negative regulation of anoikis [ISO]
- negative regulation of apoptotic process [IDA, IGI, IMP, ISO, ISS]
- negative regulation of apoptotic signaling pathway [IDA, ISO]
- negative regulation of calcium ion transport into cytosol [IGI]
- negative regulation of cell growth [IMP]
- negative regulation of cell migration [IMP]
- negative regulation of cell proliferation [IMP]
- negative regulation of cellular pH reduction [ISO]
- negative regulation of extrinsic apoptotic signaling pathway in absence of ligand [ISO]
- negative regulation of intrinsic apoptotic signaling pathway [IBA, ISO]
- negative regulation of mitotic cell cycle [IDA]
- negative regulation of myeloid cell apoptotic process [IDA]
- negative regulation of neuron apoptotic process [IDA, IMP, ISO]
- negative regulation of ossification [IMP]
- negative regulation of osteoblast proliferation [IMP]
- negative regulation of retinal cell programmed cell death [IMP]
- neuron apoptotic process [IGI, IMP]
- oocyte development [IMP]
- organ growth [IMP]
- organ morphogenesis [IMP]
- ossification [IMP]
- ovarian follicle development [IMP]
- peptidyl-serine phosphorylation [IDA]
- peptidyl-threonine phosphorylation [IDA]
- pigment granule organization [IMP]
- pigmentation [IMP]
- positive regulation of B cell proliferation [ISO]
- positive regulation of catalytic activity [IMP]
- positive regulation of cell growth [ISO]
- positive regulation of cell proliferation [IDA]
- positive regulation of developmental pigmentation [IGI, IMP]
- positive regulation of melanocyte differentiation [IMP]
- positive regulation of multicellular organism growth [IMP]
- positive regulation of neuron maturation [IMP]
- positive regulation of peptidyl-serine phosphorylation [IGI]
- positive regulation of skeletal muscle fiber development [IMP]
- positive regulation of smooth muscle cell migration [IMP]
- post-embryonic development [IGI, IMP]
- protein dephosphorylation [IDA]
- protein polyubiquitination [ISO]
- reactive oxygen species metabolic process [IMP]
- regulation of apoptotic process [IGI]
- regulation of calcium ion transport [ISO]
- regulation of catalytic activity [IMP]
- regulation of cell cycle [IMP]
- regulation of cell-matrix adhesion [IMP]
- regulation of developmental pigmentation [IGI]
- regulation of gene expression [IMP]
- regulation of glycoprotein biosynthetic process [IMP]
- regulation of mitochondrial membrane permeability [IDA]
- regulation of mitochondrial membrane potential [IDA]
- regulation of nitrogen utilization [IGI]
- regulation of programmed cell death [IGI]
- regulation of protein heterodimerization activity [ISO]
- regulation of protein homodimerization activity [ISO]
- regulation of protein localization [IMP]
- regulation of protein stability [IMP]
- regulation of transmembrane transporter activity [ISO]
- regulation of viral genome replication [IDA]
- release of cytochrome c from mitochondria [IDA]
- renal system process [IMP]
- response to UV-B [IMP]
- response to acid chemical [IDA]
- response to cytokine [IMP, ISO]
- response to drug [IDA, ISO]
- response to gamma radiation [IMP]
- response to glucocorticoid [IDA, IMP]
- response to hydrogen peroxide [IMP]
- response to iron ion [ISO]
- response to ischemia [IMP]
- response to nicotine [ISO]
- response to oxidative stress [IMP]
- response to steroid hormone [IMP]
- response to toxic substance [IMP, ISO]
- single organismal cell-cell adhesion [IMP]
- spleen development [IGI, IMP]
- thymus development [IGI, IMP]
- transmembrane transport [ISO]
- ureteric bud development [IMP]
Gene Ontology Molecular Function- BH domain binding [ISO]
- BH3 domain binding [ISO]
- channel activity [ISO]
- channel inhibitor activity [ISO]
- identical protein binding [ISO]
- protease binding [ISO]
- protein binding [IPI]
- protein heterodimerization activity [IPI, ISO]
- protein homodimerization activity [IBA, ISO]
- protein phosphatase 2A binding [IDA]
- protein phosphatase binding [IDA]
- transcription factor binding [IPI]
- ubiquitin protein ligase binding [ISO]
- BH domain binding [ISO]
- BH3 domain binding [ISO]
- channel activity [ISO]
- channel inhibitor activity [ISO]
- identical protein binding [ISO]
- protease binding [ISO]
- protein binding [IPI]
- protein heterodimerization activity [IPI, ISO]
- protein homodimerization activity [IBA, ISO]
- protein phosphatase 2A binding [IDA]
- protein phosphatase binding [IDA]
- transcription factor binding [IPI]
- ubiquitin protein ligase binding [ISO]
Gene Ontology Cellular Component
- cell [IGI]
- cytoplasm [IDA, ISO]
- cytosol [IDA]
- endoplasmic reticulum [IDA, IGI, ISO]
- endoplasmic reticulum membrane [IDA]
- intracellular [IDA, IMP]
- membrane [IDA, ISO]
- mitochondrial membrane [IDA]
- mitochondrial outer membrane [IBA, ISO]
- mitochondrion [IDA, ISO]
- myelin sheath [IDA]
- nuclear membrane [IDA, ISO]
- nucleus [IDA, ISO]
- pore complex [ISO]
Mus musculus
PREY
PPP3CA
2900074D19Rik, CN, Caln, Calna, CnA
protein phosphatase 3, catalytic subunit, alpha isoform
GO Process (22)
GO Function (10)
GO Component (9)
Gene Ontology Biological Process
- G1/S transition of mitotic cell cycle [IMP]
- calcineurin-NFAT signaling cascade [IDA, IGI, ISO]
- calcium ion transport [IMP]
- calcium-mediated signaling [IGI]
- cardiac muscle hypertrophy in response to stress [IGI]
- cellular response to drug [ISO]
- cellular response to glucose stimulus [ISO]
- dephosphorylation [IDA]
- multicellular organismal response to stress [IDA]
- negative regulation of chromatin binding [IMP]
- negative regulation of dendrite morphogenesis [IMP]
- negative regulation of insulin secretion [ISO]
- positive regulation of NFAT protein import into nucleus [IDA, IMP, ISO]
- positive regulation of cardiac muscle hypertrophy in response to stress [IDA]
- positive regulation of transcription from RNA polymerase II promoter [IDA, IGI, ISO]
- protein dephosphorylation [IMP, ISO]
- protein import into nucleus [IDA]
- regulation of excitatory postsynaptic membrane potential [IGI]
- regulation of synaptic transmission [IMP]
- response to calcium ion [ISO]
- skeletal muscle fiber development [IMP]
- transition between fast and slow fiber [IDA]
Gene Ontology Molecular Function- calcium-dependent protein serine/threonine phosphatase activity [ISO]
- calmodulin binding [ISO]
- calmodulin-dependent protein phosphatase activity [ISO]
- drug binding [ISO]
- enzyme binding [ISO]
- phosphoprotein phosphatase activity [IDA, ISO]
- protein binding [IPI]
- protein dimerization activity [ISO]
- protein heterodimerization activity [ISO]
- protein serine/threonine phosphatase activity [ISO]
- calcium-dependent protein serine/threonine phosphatase activity [ISO]
- calmodulin binding [ISO]
- calmodulin-dependent protein phosphatase activity [ISO]
- drug binding [ISO]
- enzyme binding [ISO]
- phosphoprotein phosphatase activity [IDA, ISO]
- protein binding [IPI]
- protein dimerization activity [ISO]
- protein heterodimerization activity [ISO]
- protein serine/threonine phosphatase activity [ISO]
Gene Ontology Cellular Component
Mus musculus
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Calcium-dependent interaction of calcineurin with Bcl-2 in neuronal tissue.
Calcineurin, a calmodulin-dependent protein phosphatase, regulates transcription and possibly apoptosis. Previous studies demonstrated that in baby hamster kidney-21 cells after co-transfection calcineurin interacts with Bcl-2, thereby altering transcription and apoptosis. Using co-immunoprecipitation and subcellular fractionation techniques, we observed that calcineurin occurred as a complex with Bcl-2 in various regions of rat and mouse brain. The calcineurin-Bcl-2 complex was identified in ... [more]
Neuroscience Mar. 06, 2003; 117(3);541-55 [Pubmed: 12617961]
Throughput
- Low Throughput
Curated By
- BioGRID