BAIT
GRIK1
A830007B11Rik, D16Ium24, D16Ium24e, GluK1, GluK5, Glur-5, Glur5, Glurbeta1
glutamate receptor, ionotropic, kainate 1
GO Process (18)
GO Function (8)
GO Component (12)
Gene Ontology Biological Process
- adult behavior [IMP]
- behavioral response to pain [IMP]
- cation transmembrane transport [ISO]
- ion transmembrane transport [IGI, ISO]
- ionotropic glutamate receptor signaling pathway [IGI, ISO]
- membrane depolarization [IMP]
- negative regulation of synaptic transmission, GABAergic [ISO]
- negative regulation of synaptic transmission, glutamatergic [IGI, ISO]
- nervous system development [ISO]
- positive regulation of gamma-aminobutyric acid secretion [IMP]
- positive regulation of synaptic transmission, GABAergic [IMP, ISO]
- regulation of excitatory postsynaptic membrane potential [IGI, IMP]
- regulation of inhibitory postsynaptic membrane potential [IGI, IMP]
- regulation of ion transmembrane transport [ISO]
- regulation of long-term neuronal synaptic plasticity [TAS]
- regulation of membrane potential [IDA, IMP]
- regulation of short-term neuronal synaptic plasticity [ISO, TAS]
- synaptic transmission, glutamatergic [IGI, IMP]
Gene Ontology Molecular Function- drug binding [ISO]
- extracellular-glutamate-gated ion channel activity [IBA, ISO]
- glutamate binding [ISO]
- ionotropic glutamate receptor activity [ISO]
- kainate selective glutamate receptor activity [IDA, IGI, IMP, ISO]
- protein binding [IPI]
- protein homodimerization activity [ISO]
- voltage-gated cation channel activity [ISO]
- drug binding [ISO]
- extracellular-glutamate-gated ion channel activity [IBA, ISO]
- glutamate binding [ISO]
- ionotropic glutamate receptor activity [ISO]
- kainate selective glutamate receptor activity [IDA, IGI, IMP, ISO]
- protein binding [IPI]
- protein homodimerization activity [ISO]
- voltage-gated cation channel activity [ISO]
Gene Ontology Cellular Component
- dendrite [IDA, ISO]
- ionotropic glutamate receptor complex [IC, ISO]
- kainate selective glutamate receptor complex [IPI]
- membrane [IDA]
- neuronal cell body [ISO]
- neuronal postsynaptic density [IDA]
- postsynaptic density [IDA]
- postsynaptic membrane [IBA]
- presynaptic membrane [IDA]
- receptor complex [ISO]
- synapse [IDA]
- terminal bouton [ISO]
Mus musculus
PREY
GRIK2
AW124492, GluK2, Glur-6, Glur6, Glurbeta2
glutamate receptor, ionotropic, kainate 2 (beta 2)
GO Process (22)
GO Function (10)
GO Component (16)
Gene Ontology Biological Process
- behavioral fear response [IMP]
- cellular calcium ion homeostasis [IMP]
- intracellular protein transport [IDA]
- ion transmembrane transport [IGI]
- ionotropic glutamate receptor signaling pathway [IGI, ISO]
- negative regulation of neuron apoptotic process [IGI]
- negative regulation of synaptic transmission, glutamatergic [IGI, ISO]
- neuron apoptotic process [ISO]
- neuronal action potential [IMP]
- positive regulation of neuron apoptotic process [ISO]
- positive regulation of synaptic transmission [ISO]
- receptor clustering [ISO]
- regulation of JNK cascade [ISO]
- regulation of excitatory postsynaptic membrane potential [IGI, IMP]
- regulation of inhibitory postsynaptic membrane potential [IGI, IMP]
- regulation of long-term neuronal synaptic plasticity [IMP]
- regulation of membrane potential [IDA, IGI, IMP]
- regulation of short-term neuronal synaptic plasticity [IMP, ISO]
- regulation of synaptic transmission [ISO]
- signal transduction [ISO]
- synaptic transmission [IGI, IMP, ISO]
- synaptic transmission, glutamatergic [IMP]
Gene Ontology Molecular Function- PDZ domain binding [ISO]
- extracellular-glutamate-gated ion channel activity [IBA]
- glutamate receptor activity [ISO]
- identical protein binding [ISO]
- ionotropic glutamate receptor activity [IMP]
- kainate selective glutamate receptor activity [IDA, IGI, IMP, ISO]
- protein binding [IPI]
- protein homodimerization activity [ISO]
- ubiquitin conjugating enzyme binding [ISO]
- ubiquitin protein ligase binding [ISO]
- PDZ domain binding [ISO]
- extracellular-glutamate-gated ion channel activity [IBA]
- glutamate receptor activity [ISO]
- identical protein binding [ISO]
- ionotropic glutamate receptor activity [IMP]
- kainate selective glutamate receptor activity [IDA, IGI, IMP, ISO]
- protein binding [IPI]
- protein homodimerization activity [ISO]
- ubiquitin conjugating enzyme binding [ISO]
- ubiquitin protein ligase binding [ISO]
Gene Ontology Cellular Component
- axon [ISO]
- cell [IMP]
- dendrite [IBA, ISO]
- dendrite cytoplasm [ISO]
- integral component of plasma membrane [ISO]
- intracellular [IDA]
- ionotropic glutamate receptor complex [IC, ISO]
- kainate selective glutamate receptor complex [IPI]
- membrane [IDA]
- neuronal cell body [IDA]
- perikaryon [ISO]
- postsynaptic density [IDA]
- postsynaptic membrane [IDA]
- presynaptic membrane [IDA]
- synapse [IDA, ISO, TAS]
- terminal bouton [ISO]
Mus musculus
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Localization of glutamate receptors to distal dendrites depends on subunit composition and the kinesin motor protein KIF17.
Correct glutamate receptor localization in neurons is crucial for neurotransmission in the brain. Here we investigated the mechanisms underlying localization of kainate GluR5 receptors to dendrites in cultured hippocampal neurons. We find that the GluR5 distribution depends on association with GluR6 and KA2 subunits. The GluR5 subunit was expressed in distal dendrites only when GluR6 and KA2 subunits were present, ... [more]
Mol. Cell. Neurosci. Feb. 01, 2007; 34(2);219-30 [Pubmed: 17174564]
Throughput
- Low Throughput
Curated By
- BioGRID