BAIT
EIF4A3
DDX48, MUK34, NMP265, NUK34, RCPS, eIF4AIII
eukaryotic translation initiation factor 4A3
GO Process (12)
GO Function (6)
GO Component (6)
Gene Ontology Biological Process
- ATP catabolic process [IDA]
- RNA metabolic process [TAS]
- cytokine-mediated signaling pathway [TAS]
- embryonic cranial skeleton morphogenesis [IMP]
- gene expression [TAS]
- mRNA metabolic process [TAS]
- mRNA splicing, via spliceosome [IC]
- negative regulation of translation [IDA]
- nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay [TAS]
- nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [IMP, TAS]
- nuclear-transcribed mRNA poly(A) tail shortening [TAS]
- positive regulation of translation [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
HBB
CD113t-C, beta-globin
hemoglobin, beta
GO Process (13)
GO Function (6)
GO Component (7)
Gene Ontology Biological Process
- bicarbonate transport [TAS]
- blood coagulation [TAS]
- hydrogen peroxide catabolic process [IDA]
- nitric oxide transport [NAS]
- oxidation-reduction process [IDA]
- oxygen transport [NAS, TAS]
- platelet aggregation [IMP]
- positive regulation of cell death [IDA]
- positive regulation of nitric oxide biosynthetic process [NAS]
- protein heterooligomerization [IDA]
- renal absorption [IMP]
- response to hydrogen peroxide [IDA]
- small molecule metabolic process [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-RNA
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and associated RNA species identified by Northern blot, RT-PCR, affinity labeling, sequencing, or microarray analysis.
Publication
Upf1 ATPase-dependent mRNP disassembly is required for completion of nonsense- mediated mRNA decay.
Cellular mRNAs exist in messenger ribonucleoprotein (mRNP) complexes, which undergo transitions during the lifetime of the mRNAs and direct posttranscriptional gene regulation. A final posttranscriptional step in gene expression is the turnover of the mRNP, which involves degradation of the mRNA and recycling of associated proteins. How tightly associated protein components are released from degrading mRNPs is unknown. Here, we ... [more]
Cell Dec. 10, 2010; 143(6);938-50 [Pubmed: 21145460]
Throughput
- Low Throughput
Additional Notes
- figure 6.
Curated By
- BioGRID