BAIT
CDC25
sal2, SPAC24H6.05
M phase inducer tyrosine phosphatase Cdc25
GO Process (6)
GO Function (3)
GO Component (3)
Gene Ontology Biological Process
- mitotic DNA replication checkpoint [IMP]
- peptidyl-tyrosine dephosphorylation involved in activation of protein kinase activity [IDA]
- positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G2/M transition of mitotic cell cycle [IMP]
- regulation of G2/M transition of mitotic cell cycle [IMP]
- regulation of cell size [NAS]
- signal transduction involved in intra-S DNA damage checkpoint [IMP]
Gene Ontology Molecular Function
Schizosaccharomyces pombe (972h)
PREY
HIP1
hir1, SPBC31F10.13c
hira protein, histone chaperone Hip1
GO Process (6)
GO Function (2)
GO Component (4)
Gene Ontology Biological Process
- DNA replication-independent nucleosome assembly [TAS]
- cellular response to nitrogen starvation [IMP]
- chromatin silencing at centromere [IMP]
- chromatin silencing at silent mating-type cassette [IMP]
- mitotic sister chromatid segregation [IMP]
- negative regulation of transcription from RNA polymerase II promoter [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Schizosaccharomyces pombe (972h)
Synthetic Lethality
A genetic interaction is inferred when mutations or deletions in separate genes, each of which alone causes a minimal phenotype, result in lethality when combined in the same cell under a given condition.
Publication
The Schizosaccharomyces pombe HIRA-like protein Hip1 is required for the periodic expression of histone genes and contributes to the function of complex centromeres.
HIRA-like (Hir) proteins are evolutionarily conserved and are implicated in the assembly of repressive chromatin. In Saccharomyces cerevisiae, Hir proteins contribute to the function of centromeres. However, S. cerevisiae has point centromeres that are structurally different from the complex centromeres of metazoans. In contrast, Schizosaccharomyces pombe has complex centromeres whose domain structure is conserved with that of human centromeres. Therefore, ... [more]
Mol. Cell. Biol. May. 01, 2004; 24(10);4309-20 [Pubmed: 15121850]
Throughput
- Low Throughput
Ontology Terms
- phenotype: inviable (APO:0000112)
Curated By
- BioGRID