GIPC1
Gene Ontology Biological Process
- G-protein coupled receptor signaling pathway [TAS]
- endothelial cell migration [IMP]
- glutamate secretion [IMP]
- negative regulation of proteasomal ubiquitin-dependent protein catabolic process [IDA]
- positive regulation of GTPase activity [TAS]
- positive regulation of cytokinesis [ISO]
- positive regulation of transforming growth factor beta receptor signaling pathway [IDA]
- protein targeting [IMP, IPI]
- regulation of protein stability [IDA]
- regulation of synaptic plasticity [IMP]
- synaptic transmission [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- brush border [ISO]
- cell [IMP]
- cell cortex [ISO]
- cytoplasm [IDA]
- cytoplasmic membrane-bounded vesicle [ISO]
- cytosol [IDA, ISO]
- dendritic shaft [IDA]
- dendritic spine [IDA]
- endocytic vesicle [ISO]
- extracellular vesicular exosome [ISO]
- intracellular [IMP]
- membrane [IDA, ISO]
- synaptic vesicle [IDA]
- vesicle membrane [IDA]
PLEKHG5
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
A PDZ-binding motif as a critical determinant of Rho guanine exchange factor function and cell phenotype.
We identified a Rho guanine exchange factor (GEF) expressed as two splice variants, which differ only in either having or lacking a Postsynaptic density 95, Disk large, Zona occludens-1 (PDZ) motif. The PDZ adaptor protein synectin bound the longer splice variant, Syx1, which was targeted to the plasma membrane in a synectin-dependent manner. The shorter variant, Syx2, was diffusely distributed ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| PLEKHG5 GIPC1 | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - | |
| PLEKHG5 GIPC1 | Protein-peptide Protein-peptide An interaction is detected between a protein and a peptide derived from an interaction partner. This includes phage display experiments. | Low | - | BioGRID | 1425762 |
Curated By
- BioGRID