DNAJC10
Gene Ontology Biological Process
- ER-associated ubiquitin-dependent protein catabolic process [IDA, ISO]
- intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress [ISO]
- negative regulation of protein phosphorylation [ISO]
- oxidation-reduction process [ISO]
- positive regulation of ATPase activity [IMP]
- protein folding in endoplasmic reticulum [ISO]
- response to endoplasmic reticulum stress [ISO]
Gene Ontology Molecular Function- ATPase activator activity [IMP]
- ATPase binding [IPI, ISO]
- Hsp70 protein binding [ISO]
- chaperone binding [IDA, ISO]
- disulfide oxidoreductase activity [IDA]
- misfolded protein binding [ISO]
- oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor [IDA]
- protein binding [IPI]
- protein disulfide oxidoreductase activity [IDA, ISO]
- ATPase activator activity [IMP]
- ATPase binding [IPI, ISO]
- Hsp70 protein binding [ISO]
- chaperone binding [IDA, ISO]
- disulfide oxidoreductase activity [IDA]
- misfolded protein binding [ISO]
- oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor [IDA]
- protein binding [IPI]
- protein disulfide oxidoreductase activity [IDA, ISO]
Gene Ontology Cellular Component
HSPA5
Gene Ontology Biological Process
- ER overload response [IDA]
- activation of signaling protein activity involved in unfolded protein response [IMP]
- cellular response to glucose starvation [ISO]
- cellular response to interleukin-4 [IDA]
- cerebellar Purkinje cell layer development [IMP]
- cerebellum structural organization [IMP]
- maintenance of protein localization in endoplasmic reticulum [ISO]
- negative regulation of apoptotic process [ISO]
- negative regulation of transforming growth factor beta receptor signaling pathway [IGI]
- positive regulation of cell migration [ISO]
- positive regulation of embryonic development [TAS]
- positive regulation of protein ubiquitination [IMP]
- proteolysis involved in cellular protein catabolic process [IDA]
- response to endoplasmic reticulum stress [ISO]
- toxin transport [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- COP9 signalosome [ISO]
- cell surface [IDA]
- endoplasmic reticulum [IDA, ISO]
- endoplasmic reticulum chaperone complex [ISO]
- endoplasmic reticulum lumen [IDA]
- endoplasmic reticulum membrane [IDA]
- endoplasmic reticulum-Golgi intermediate compartment [IDA, ISO]
- extracellular vesicular exosome [ISO]
- focal adhesion [ISO]
- integral component of endoplasmic reticulum membrane [ISO]
- membrane [ISO]
- midbody [ISO]
- mitochondrion [ISO]
- myelin sheath [IDA]
- nucleus [ISO]
- plasma membrane [IDA]
- smooth endoplasmic reticulum [ISO]
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
JPDI, a novel endoplasmic reticulum-resident protein containing both a BiP-interacting J-domain and thioredoxin-like motifs.
Several endoplasmic reticulum (ER)-resident luminal proteins have a characteristic ER retrieval signal, KDEL, or its variants at their C terminus. Our previous work searching EST databases for proteins containing the C-terminal KDEL motif predicted some novel murine proteins, one of which designated JPDI (J-domain-containing protein disulfide isomerase-like protein) is characterized in this study. The primary structure of JPDI is unique, ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID