SRW1
Gene Ontology Biological Process
- mitotic cell cycle arrest in response to nitrogen starvation [IMP]
- negative regulation of cyclin-dependent protein serine/threonine kinase activity [IC]
- negative regulation of cyclin-dependent protein serine/threonine kinase by cyclin degradation [IMP]
- pheromone-dependent signal transduction involved in conjugation with cellular fusion [IMP]
Gene Ontology Cellular Component
CDC10
Gene Ontology Biological Process
- negative regulation of transcription, DNA-templated [IDA]
- positive regulation of transcription involved in G1/S transition of mitotic cell cycle [IMP]
- positive regulation of transcription, DNA-templated [IDA]
- rRNA transcription [IDA]
- regulation of transcription involved in G1/S transition of mitotic cell cycle [IMP]
- transcription from RNA polymerase II promoter [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Synthetic Lethality
A genetic interaction is inferred when mutations or deletions in separate genes, each of which alone causes a minimal phenotype, result in lethality when combined in the same cell under a given condition.
Publication
Fission yeast Ste9, a homolog of Hct1/Cdh1 and Fizzy-related, is a novel negative regulator of cell cycle progression during G1-phase.
When proliferating fission yeast cells are exposed to nitrogen starvation, they initiate conjugation and differentiate into ascospores. Cell cycle arrest in the G1-phase is one of the prerequisites for cell differentiation, because conjugation occurs only in the pre-Start G1-phase. The role of ste9(+) in the cell cycle progression was investigated. Ste9 is a WD-repeat protein that is highly homologous to ... [more]
Throughput
- Low Throughput
Ontology Terms
- phenotype: inviable (APO:0000112)
- phenotype: heat sensitivity (APO:0000147)
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| CDC10 SRW1 | Dosage Rescue Dosage Rescue A genetic interaction is inferred when over expression or increased dosage of one gene rescues the lethality or growth defect of a strain that is mutated or deleted for another gene. | Low | - | BioGRID | 2534997 |
Curated By
- BioGRID