A genetic interaction is inferred when mutations or deletions in separate genes, each of which alone causes a minimal phenotype, result in lethality when combined in the same cell under a given condition.

Publication

The fission yeast spSet1p is a histone H3-K4 methyltransferase that functions in telomere maintenance and DNA repair in an ATM kinase Rad3-dependent pathway.

Kanoh J, Francesconi S, Collura A, Schramke V, Ishikawa F, Baldacci G, Geli V

We have characterized spSet1p, the Schizosaccharomyces pombe ortholog of the budding yeast histone H3 methyltransferase Set1p. SpSet1p catalyzes methylation of H3 at K4, in vivo and in vitro. Deleting spset1 partially affects telomeric and centromeric silencing. Strikingly, lack of spSet1p causes elongation of telomeres in wild-type cells and in most DNA damage checkpoint rad mutant cells, but not in cells ... [more]

J. Mol. Biol. Feb. 28, 2003; 326(4);1081-94 [Pubmed: 12589755]

Throughput

Low Throughput

Ontology Terms

phenotype: inviable (APO:0000112)
phenotype: heat sensitivity (APO:0000147)

Additional Notes

double mutants show reduced viability at 37 degrees

Related interactions

Interaction	Experimental Evidence Code	Dataset	Throughput	Score	Curated By	Notes
CDC6 CRB2	Phenotypic Enhancement Phenotypic Enhancement A genetic interaction is inferred when mutation or overexpression of one gene results in enhancement of any phenotype (other than lethality/growth defect) associated with mutation or over expression of another gene.	Mochida S (2004)	Low	-	BioGRID	798431
CDC6 CRB2	Phenotypic Suppression Phenotypic Suppression A genetic interaction is inferred when mutation or over expression of one gene results in suppression of any phenotype (other than lethality/growth defect) associated with mutation or over expression of another gene.	Saka Y (1997)	Low	-	BioGRID	795460

Curated By

BioGRID

Interaction Summary

CRB2

Gene Ontology Biological Process

Gene Ontology Molecular Function

protein binding [IPI]

Gene Ontology Cellular Component

CDC6