STAT1
Gene Ontology Biological Process
- JAK-STAT cascade [ISO]
- activation of cysteine-type endopeptidase activity involved in apoptotic process [IMP]
- blood circulation [ISO]
- cellular response to insulin stimulus [ISO]
- cellular response to interferon-beta [ISO]
- cellular response to lipopolysaccharide [IMP]
- cytokine-mediated signaling pathway [IDA]
- interferon-gamma-mediated signaling pathway [IMP, ISO]
- lipopolysaccharide-mediated signaling pathway [IDA]
- negative regulation by virus of viral protein levels in host cell [ISO]
- negative regulation of I-kappaB kinase/NF-kappaB signaling [ISO]
- negative regulation of angiogenesis [ISO]
- negative regulation of endothelial cell proliferation [ISO]
- negative regulation of macrophage fusion [IMP]
- positive regulation of cell proliferation [ISO]
- positive regulation of smooth muscle cell proliferation [ISO]
- positive regulation of transcription from RNA polymerase II promoter [ISO]
- positive regulation of transcription, DNA-templated [ISO]
- regulation of transcription, DNA-templated [IMP]
- renal tubule development [ISO]
- response to bacterium [IDA]
- response to cAMP [ISO]
- response to cytokine [ISO]
- response to drug [ISO]
- response to exogenous dsRNA [IDA]
- response to lipopolysaccharide [IDA]
- response to mechanical stimulus [ISO]
- response to nutrient [ISO]
- response to peptide hormone [ISO]
- transcription from RNA polymerase II promoter [ISO]
- transcription, DNA-templated [IMP]
- tumor necrosis factor-mediated signaling pathway [ISO]
- type I interferon signaling pathway [IMP]
Gene Ontology Molecular Function- CCR5 chemokine receptor binding [ISO]
- DNA binding [ISO]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding [ISO]
- RNA polymerase II core promoter sequence-specific DNA binding [ISO]
- RNA polymerase II core promoter sequence-specific DNA binding transcription factor activity [ISO]
- double-stranded DNA binding [ISO]
- enzyme binding [ISO]
- identical protein binding [ISO]
- protein binding [IPI]
- protein homodimerization activity [ISO]
- protein phosphatase 2A binding [ISO]
- sequence-specific DNA binding [ISO]
- sequence-specific DNA binding transcription factor activity [IMP]
- tumor necrosis factor receptor binding [ISO]
- CCR5 chemokine receptor binding [ISO]
- DNA binding [ISO]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding [ISO]
- RNA polymerase II core promoter sequence-specific DNA binding [ISO]
- RNA polymerase II core promoter sequence-specific DNA binding transcription factor activity [ISO]
- double-stranded DNA binding [ISO]
- enzyme binding [ISO]
- identical protein binding [ISO]
- protein binding [IPI]
- protein homodimerization activity [ISO]
- protein phosphatase 2A binding [ISO]
- sequence-specific DNA binding [ISO]
- sequence-specific DNA binding transcription factor activity [IMP]
- tumor necrosis factor receptor binding [ISO]
FBXO2
Gene Ontology Biological Process
- ER-associated ubiquitin-dependent protein catabolic process [IDA]
- SCF-dependent proteasomal ubiquitin-dependent protein catabolic process [IDA]
- glycoprotein catabolic process [IDA]
- negative regulation of cell proliferation [ISO]
- protein ubiquitination [IDA]
- regulation of protein ubiquitination [IDA]
- ubiquitin-dependent protein catabolic process [IDA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
ERK and the F-box protein betaTRCP target STAT1 for degradation.
The transcription factor STAT1 has roles in development, homeostasis, cellular differentiation, and apoptosis and has been postulated to function as a tumor suppressor. STAT1 is activated by tyrosine or serine phosphorylation in response to specific cytokines or following a variety of stress-induced stimuli. STAT1 activity is carefully regulated to prevent sustained STAT1-mediated transcription, although the molecular mechanisms involved in the ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID