MYOCD
Gene Ontology Biological Process
- cardiac muscle cell differentiation [IMP]
- cardiac ventricle development [IMP]
- cell growth involved in cardiac muscle cell development [ISO]
- cellular component maintenance [IMP]
- digestive tract development [IMP]
- ductus arteriosus closure [IMP]
- heart development [IMP]
- hepatic stellate cell activation [ISO]
- lung alveolus development [IMP]
- muscle cell differentiation [IMP]
- negative regulation of beta-amyloid clearance [ISO]
- negative regulation of cardiac muscle cell apoptotic process [IMP]
- negative regulation of cell proliferation [ISO]
- negative regulation of cyclin-dependent protein serine/threonine kinase activity [ISO]
- negative regulation of myotube differentiation [IMP]
- negative regulation of skeletal muscle cell differentiation [ISO]
- negative regulation of transcription from RNA polymerase II promoter [IGI]
- positive regulation of DNA binding [IGI]
- positive regulation of cardiac muscle cell differentiation [ISO]
- positive regulation of cardiac vascular smooth muscle cell differentiation [ISO]
- positive regulation of cell proliferation [IDA]
- positive regulation of sequence-specific DNA binding transcription factor activity [ISO]
- positive regulation of smooth muscle cell differentiation [ISO]
- positive regulation of smooth muscle contraction [ISO]
- positive regulation of transcription from RNA polymerase II promoter [IDA, IGI, ISO]
- positive regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation [ISO]
- positive regulation of transcription from RNA polymerase II promoter involved in smooth muscle cell differentiation [ISO]
- positive regulation of transcription, DNA-templated [IDA, ISO]
- positive regulation of transforming growth factor beta receptor signaling pathway [IDA]
- regulation of cell growth by extracellular stimulus [IDA]
- regulation of histone acetylation [IDA]
- regulation of myoblast differentiation [IMP]
- regulation of smooth muscle cell differentiation [ISO]
- regulation of transcription from RNA polymerase II promoter [IDA, IPI]
- smooth muscle cell differentiation [IMP, ISO]
- transcription from RNA polymerase II promoter [IPI]
- urinary bladder development [IMP]
- uterus development [IMP]
- vasculogenesis [IMP]
- ventricular cardiac muscle cell differentiation [IMP]
Gene Ontology Molecular Function- R-SMAD binding [IPI]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [ISO]
- RNA polymerase II transcription factor binding transcription factor activity [IDA, IPI]
- core promoter sequence-specific DNA binding [ISO]
- histone acetyltransferase binding [IPI]
- histone deacetylase binding [IPI]
- protein binding [IPI]
- transcription coactivator activity [IDA]
- transcription factor binding [ISO]
- R-SMAD binding [IPI]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [ISO]
- RNA polymerase II transcription factor binding transcription factor activity [IDA, IPI]
- core promoter sequence-specific DNA binding [ISO]
- histone acetyltransferase binding [IPI]
- histone deacetylase binding [IPI]
- protein binding [IPI]
- transcription coactivator activity [IDA]
- transcription factor binding [ISO]
Gene Ontology Cellular Component
HIST2H2BE
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Modulation of smooth muscle gene expression by association of histone acetyltransferases and deacetylases with myocardin.
Differentiation of smooth muscle cells is accompanied by the transcriptional activation of an array of muscle-specific genes controlled by serum response factor (SRF). Myocardin is a cardiac and smooth muscle-specific expressed transcriptional coactivator of SRF and is sufficient and necessary for smooth muscle gene expression. Here, we show that myocardin induces the acetylation of nucleosomal histones surrounding SRF-binding sites in ... [more]
Throughput
- Low Throughput
Additional Notes
- acetylated histones
Curated By
- BioGRID