PDIA4
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
HSPA5
Gene Ontology Biological Process
- ER overload response [ISO]
- activation of signaling protein activity involved in unfolded protein response [ISO]
- cellular response to antibiotic [IEP]
- cellular response to glucose starvation [ISO]
- cellular response to interleukin-4 [ISO]
- cerebellar Purkinje cell layer development [ISO]
- cerebellum structural organization [ISO]
- maintenance of protein localization in endoplasmic reticulum [ISO, ISS]
- negative regulation of apoptotic process [ISO]
- negative regulation of transforming growth factor beta receptor signaling pathway [ISO]
- positive regulation of cell migration [ISO, ISS]
- positive regulation of protein ubiquitination [ISO]
- proteolysis involved in cellular protein catabolic process [ISO]
- response to endoplasmic reticulum stress [IDA]
- substantia nigra development [ISO]
- toxin transport [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- COP9 signalosome [ISO]
- cell surface [ISO]
- endoplasmic reticulum [IDA, ISO, TAS]
- endoplasmic reticulum chaperone complex [ISO]
- endoplasmic reticulum lumen [ISO]
- endoplasmic reticulum membrane [ISO]
- endoplasmic reticulum-Golgi intermediate compartment [ISO]
- extracellular vesicular exosome [ISO]
- focal adhesion [ISO]
- integral component of endoplasmic reticulum membrane [ISO]
- membrane [IDA, ISO]
- midbody [ISO]
- mitochondrion [IDA]
- myelin sheath [ISO]
- nucleus [ISO]
- plasma membrane [ISO]
- smooth endoplasmic reticulum [IDA]
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Multiple molecular chaperones complex with misfolded large oligomeric glycoproteins in the endoplasmic reticulum.
Thyroglobulin (Tg), the major protein secreted by thyroid epithelial cells and precursor of thyroid hormones, is a large dimeric glycoprotein with multiple disulfide bonds. The folding and assembly of this complex molecule begins in the endoplasmic reticulum (ER) and is likely to involve a variety of reactions catalyzed by molecular chaperones (Kuznetsov, G., Chen, L. B., and Nigam, S. K. ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| HSPA5 PDIA4 | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - |
Curated By
- BioGRID