LNX2
Gene Ontology Biological Process
Gene Ontology Molecular Function
NUMBL
Gene Ontology Biological Process
- adherens junction organization [IGI]
- axonogenesis [IMP]
- cytokine-mediated signaling pathway [ISO]
- forebrain development [IMP]
- lateral ventricle development [IMP]
- nervous system development [IMP]
- neuroblast division in subventricular zone [IMP]
- neuroblast proliferation [IGI]
- positive regulation of dendrite morphogenesis [ISO]
- positive regulation of neurogenesis [IMP]
- protein metabolic process [ISO]
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
The Lnx family proteins function as molecular scaffolds for Numb family proteins.
Drosophila Numb functions as a cell fate determinant during neurogenesis. We isolated a novel mammalian protein, Lnx2, which interacts with mammalian Numb and Numblike. Lnx2 and the related Lnx1 are multimodular proteins that bind to Numb via their NPXY motifs. In addition, Lnx proteins form oligomers either via their PDZ domains binding to PDZ-binding consensus motifs located in their C-termini ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID