HDA1
Gene Ontology Biological Process
- chromatin organization involved in regulation of transcription [IMP]
- gene silencing by RNA [IMP]
- gene silencing involved in chronological cell aging [IGI, IMP]
- histone deacetylation [IDA, IMP]
- negative regulation of chromatin silencing involved in replicative cell aging [IGI, IMP]
- negative regulation of transcription by transcription factor localization [IGI]
- negative regulation of transcription from RNA polymerase II promoter [IMP]
- positive regulation of transcription from RNA polymerase II promoter [IMP]
- regulation of chromatin silencing at telomere [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- HDA1 complex [IDA, IPI]
CDH1
Gene Ontology Biological Process
- activation of mitotic anaphase-promoting complex activity [IMP]
- negative regulation of spindle pole body separation [IGI, IMP]
- positive regulation of cyclin catabolic process [IDA]
- positive regulation of mitotic metaphase/anaphase transition [IMP]
- positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process [IDA]
- regulation of cell size [IMP]
Gene Ontology Molecular Function
Dosage Lethality
A genetic interaction is inferred when over expression or increased dosage of one gene causes lethality in a strain that is mutated or deleted for another gene.
Publication
Exploring the yeast acetylome using functional genomics.
Lysine acetylation is a dynamic posttranslational modification with a well-defined role in regulating histones. The impact of acetylation on other cellular functions remains relatively uncharacterized. We explored the budding yeast acetylome with a functional genomics approach, assessing the effects of gene overexpression in the absence of lysine deacetylases (KDACs). We generated a network of 463 synthetic dosage lethal (SDL) interactions ... [more]
Throughput
- High Throughput|Low Throughput
Ontology Terms
- phenotype: colony size (APO:0000063)
- phenotype: vegetative growth (APO:0000106)
- phenotype: inviable (APO:0000112)
Additional Notes
- High Throughput: colony size reduction greater than 20% relative to wild type
- Low Throughput: spot dilution assay
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| CDH1 HDA1 | Negative Genetic Negative Genetic Mutations/deletions in separate genes, each of which alone causes a minimal phenotype, but when combined in the same cell results in a more severe fitness defect or lethality under a given condition. This term is reserved for high or low throughput studies with scores. | High | -2.81 | BioGRID | 2358691 |
Curated By
- BioGRID