BAIT
HOS2
RTL1, histone deacetylase HOS2, L000004092, L000003448, YGL194C
Histone deacetylase and subunit of Set3 and Rpd3L complexes; required for gene activation via specific deacetylation of lysines in H3 and H4 histone tails; subunit of the Set3 complex, a meiotic-specific repressor of sporulation specific genes that contains deacetylase activity; co-localizes with Cmr1p in nuclear foci in response to DNA damage by MMS
GO Process (5)
GO Function (2)
GO Component (4)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Saccharomyces cerevisiae (S288c)
PREY
LIN1
SNU40, YHR156C
Non-essential component of U5 snRNP; nuclear protein; physically interacts with Irr1p of cohesin complex; may link together proteins involved in chromosome segregation, mRNA splicing and DNA replication
GO Process (0)
GO Function (1)
GO Component (4)
Gene Ontology Molecular Function
Saccharomyces cerevisiae (S288c)
Dosage Lethality
A genetic interaction is inferred when over expression or increased dosage of one gene causes lethality in a strain that is mutated or deleted for another gene.
Publication
Exploring the yeast acetylome using functional genomics.
Lysine acetylation is a dynamic posttranslational modification with a well-defined role in regulating histones. The impact of acetylation on other cellular functions remains relatively uncharacterized. We explored the budding yeast acetylome with a functional genomics approach, assessing the effects of gene overexpression in the absence of lysine deacetylases (KDACs). We generated a network of 463 synthetic dosage lethal (SDL) interactions ... [more]
Cell May. 11, 2012; 149(4);936-48 [Pubmed: 22579291]
Throughput
- High Throughput|Low Throughput
Ontology Terms
- phenotype: vegetative growth (APO:0000106)
- phenotype: inviable (APO:0000112)
- phenotype: colony size (APO:0000063)
Additional Notes
- High Throughput: colony size reduction greater than 20% relative to wild type
- Low Throughput: spot dilution assay
Curated By
- BioGRID