BAIT

MCB1

SPAC1687.04
MCM binding protein homolog Mcb1
Schizosaccharomyces pombe (972h)
PREY

CDC45

goa1, sna41, SPAC17D4.02
DNA replication pre-initiation complex subunit Cdc45
GO Process (1)
GO Function (2)
GO Component (5)

Gene Ontology Biological Process

Gene Ontology Molecular Function

Gene Ontology Cellular Component

Schizosaccharomyces pombe (972h)

Synthetic Growth Defect

A genetic interaction is inferred when mutations in separate genes, each of which alone causes a minimal phenotype, result in a significant growth defect under a given condition when combined in the same cell.

Publication

The Fission Yeast MCM-BP, Mcb1, Regulates MCM Function during Pre-Replicative Complex Formation in DNA Replication.

Santosa V, Martha S, Hirose N, Tanaka K

The MCM complex is a replicative helicase, which is essential for chromosome DNA replication. In recent years, the identification of a novel MCM-binding protein (MCM-BP) in most eukaryotes has led to numerous studies investigating its function and its relationship to the MCM complex. However, the mechanisms by which MCM-BP functions and associates with MCM complexes are not well understood; in ... [more]

J. Biol. Chem. Jan. 15, 2013; 0(0); [Pubmed: 23322785]

Throughput

  • Low Throughput

Ontology Terms

  • vegetative growth (APO:0000106)
  • heat sensitivity (APO:0000147)

Additional Notes

  • double mutants show increased temperature sensitivity

Curated By

  • BioGRID