TFRC
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- blood microparticle [IDA]
- cell surface [IDA]
- coated pit [IDA]
- cytoplasmic membrane-bounded vesicle [IDA]
- endosome [IDA]
- extracellular region [IDA]
- extracellular space [IDA]
- extracellular vesicular exosome [IDA]
- integral component of plasma membrane [TAS]
- intracellular membrane-bounded organelle [IDA]
- membrane [NAS]
- plasma membrane [TAS]
- recycling endosome [IDA]
- vesicle [IDA]
B4GALT1
Gene Ontology Biological Process
- Notch signaling pathway [TAS]
- binding of sperm to zona pellucida [TAS]
- carbohydrate metabolic process [TAS]
- cellular protein metabolic process [TAS]
- glycosaminoglycan metabolic process [TAS]
- keratan sulfate biosynthetic process [TAS]
- keratan sulfate metabolic process [TAS]
- multicellular organism reproduction [TAS]
- oligosaccharide biosynthetic process [IDA, NAS]
- post-translational protein modification [TAS]
- protein N-linked glycosylation [IDA]
- protein N-linked glycosylation via asparagine [TAS]
- single fertilization [TAS]
- small molecule metabolic process [TAS]
Gene Ontology Molecular Function- N-acetyllactosamine synthase activity [IDA]
- UDP-galactosyltransferase activity [IDA]
- alpha-tubulin binding [IDA]
- beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase activity [IDA]
- beta-tubulin binding [IPI]
- galactosyltransferase activity [NAS]
- lactose synthase activity [IDA]
- manganese ion binding [IDA]
- protein homodimerization activity [IDA]
- N-acetyllactosamine synthase activity [IDA]
- UDP-galactosyltransferase activity [IDA]
- alpha-tubulin binding [IDA]
- beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase activity [IDA]
- beta-tubulin binding [IPI]
- galactosyltransferase activity [NAS]
- lactose synthase activity [IDA]
- manganese ion binding [IDA]
- protein homodimerization activity [IDA]
Gene Ontology Cellular Component
Reconstituted Complex
An interaction is inferred between proteins in vitro. This can include proteins in recombinant form or proteins isolated directly from cells with recombinant or purified bait. For example, GST pull-down assays where a GST-tagged protein is first isolated and then used to fish interactors from cell lysates are considered reconstituted complexes (e.g. PUBMED: 14657240, Fig. 4A or PUBMED: 14761940, Fig. 5). This can also include gel-shifts, surface plasmon resonance, isothermal titration calorimetry (ITC) and bio-layer interferometry (BLI) experiments. The bait-hit directionality may not be clear for 2 interacting proteins. In these cases the directionality is up to the discretion of the curator.
Publication
Golgi retention mechanism of beta-1,4-galactosyltransferase. Membrane-spanning domain-dependent homodimerization and association with alpha- and beta-tubulins.
Recent studies on proteins residing in the Golgi complex revealed that the membrane-spanning domain of these proteins are largely responsible for their retention in the Golgi complex. We show here that beta-1,4-galactosyltransferase (GT) forms homodimers and large oligomers in vivo, and the formation of the homodimers is dependent on cysteine and histidine residues within the transmembrane domain. Double mutations of ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID