CALR
Gene Ontology Biological Process
- activation of signaling protein activity involved in unfolded protein response [TAS]
- antigen processing and presentation of exogenous peptide antigen via MHC class I [TAS]
- antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent [TAS]
- antigen processing and presentation of peptide antigen via MHC class I [TAS]
- cell cycle arrest [IGI]
- cellular calcium ion homeostasis [TAS]
- cellular protein metabolic process [TAS]
- cellular senescence [IGI]
- endoplasmic reticulum unfolded protein response [TAS]
- glucocorticoid receptor signaling pathway [TAS]
- negative regulation of intracellular steroid hormone receptor signaling pathway [IDA]
- negative regulation of neuron differentiation [IDA]
- negative regulation of retinoic acid receptor signaling pathway [IDA]
- negative regulation of transcription from RNA polymerase II promoter [IDA]
- negative regulation of transcription, DNA-templated [IDA]
- negative regulation of translation [ISS, TAS]
- peptide antigen assembly with MHC class I protein complex [ISS]
- positive regulation of DNA replication [IGI]
- positive regulation of cell cycle [IGI]
- positive regulation of cell proliferation [IGI]
- positive regulation of dendritic cell chemotaxis [IMP]
- positive regulation of phagocytosis [ISS]
- positive regulation of substrate adhesion-dependent cell spreading [IMP]
- post-translational protein modification [TAS]
- protein N-linked glycosylation via asparagine [TAS]
- protein export from nucleus [IDA]
- protein folding [TAS]
- protein localization to nucleus [IDA]
- protein maturation by protein folding [TAS]
- protein stabilization [ISS, TAS]
- regulation of apoptotic process [TAS]
- regulation of transcription, DNA-templated [TAS]
- sequestering of calcium ion [TAS]
Gene Ontology Molecular Function- DNA binding [NAS]
- androgen receptor binding [IDA]
- calcium ion binding [ISS, TAS]
- carbohydrate binding [TAS]
- chaperone binding [TAS]
- complement component C1q binding [TAS]
- glycoprotein binding [IPI]
- integrin binding [IPI]
- mRNA binding [IDA]
- poly(A) RNA binding [IDA]
- protein binding [IPI]
- protein binding involved in protein folding [TAS]
- ubiquitin protein ligase binding [IPI]
- unfolded protein binding [TAS]
- zinc ion binding [TAS]
- DNA binding [NAS]
- androgen receptor binding [IDA]
- calcium ion binding [ISS, TAS]
- carbohydrate binding [TAS]
- chaperone binding [TAS]
- complement component C1q binding [TAS]
- glycoprotein binding [IPI]
- integrin binding [IPI]
- mRNA binding [IDA]
- poly(A) RNA binding [IDA]
- protein binding [IPI]
- protein binding involved in protein folding [TAS]
- ubiquitin protein ligase binding [IPI]
- unfolded protein binding [TAS]
- zinc ion binding [TAS]
Gene Ontology Cellular Component
- MHC class I peptide loading complex [ISS]
- cell surface [TAS]
- cytoplasm [IDA]
- cytosol [IDA]
- endocytic vesicle lumen [TAS]
- endoplasmic reticulum [IDA, TAS]
- endoplasmic reticulum lumen [IDA, TAS]
- extracellular region [TAS]
- extracellular space [IDA]
- extracellular vesicular exosome [IDA]
- focal adhesion [IDA]
- integral component of lumenal side of endoplasmic reticulum membrane [TAS]
- intracellular [TAS]
- membrane [IDA]
- nucleus [IDA]
- perinuclear region of cytoplasm [IDA]
- polysome [ISS]
HLA-E
Gene Ontology Biological Process
- antigen processing and presentation of endogenous peptide antigen via MHC class Ib [IDA]
- antigen processing and presentation of exogenous peptide antigen via MHC class I [TAS]
- antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent [TAS]
- antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent [TAS]
- antigen processing and presentation of peptide antigen via MHC class I [TAS]
- cytokine-mediated signaling pathway [TAS]
- innate immune response [TAS]
- interferon-gamma-mediated signaling pathway [TAS]
- positive regulation of natural killer cell mediated immunity [IDA]
- protection from natural killer cell mediated cytotoxicity [IDA]
- regulation of immune response [TAS]
- type I interferon signaling pathway [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
TAP- and tapasin-dependent HLA-E surface expression correlates with the binding of an MHC class I leader peptide.
The human major histocompatibility complex (MHC) class lb molecule HLA-E is transcribed in most tissues but little is known about its localisation within the cell. We have recently shown that HLA-E binds signal-sequence-derived peptides from human MHC class I molecules in vitro.Using a newly characterised antibody recognising HLA-E, we show that HLA-E is expressed at the cell surface. We demonstrate ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| CALR HLA-E | Protein-peptide Protein-peptide An interaction is detected between a protein and a peptide derived from an interaction partner. This includes phage display experiments. | Low | - | BioGRID | - |
Curated By
- BioGRID