CDC42
Gene Ontology Biological Process
- budding cell apical bud growth [IMP]
- budding cell isotropic bud growth [IMP]
- conjugation with cellular fusion [IMP]
- establishment of cell polarity [IMP]
- invasive growth in response to glucose limitation [IMP]
- pheromone-dependent signal transduction involved in conjugation with cellular fusion [IGI, IMP]
- positive regulation of exocytosis [IGI, IMP, IPI]
- positive regulation of pseudohyphal growth [IMP]
- regulation of exit from mitosis [IMP]
- regulation of exocyst localization [IMP]
- regulation of initiation of mating projection growth [IMP]
- regulation of vacuole fusion, non-autophagic [IMP]
- septin ring organization [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
PEA2
Gene Ontology Biological Process
- bipolar cellular bud site selection [IMP]
- budding cell apical bud growth [IGI, IMP]
- establishment of cell polarity [IMP]
- filamentous growth [IMP]
- positive regulation of actin cytoskeleton reorganization [IMP]
- pseudohyphal growth [IMP]
- regulation of initiation of mating projection growth [IMP]
- regulation of protein localization [IMP]
- regulation of termination of mating projection growth [IMP]
Gene Ontology Cellular Component
Synthetic Lethality
A genetic interaction is inferred when mutations or deletions in separate genes, each of which alone causes a minimal phenotype, result in lethality when combined in the same cell under a given condition.
Publication
Interaction between a Ras and a Rho GTPase couples selection of a growth site to the development of cell polarity in yeast.
Polarized cell growth requires the coupling of a defined spatial site on the cell cortex to the apparatus that directs the establishment of cell polarity. In the budding yeast Saccharomyces cerevisiae, the Ras-family GTPase Rsr1p/Bud1p and its regulators select the proper site for bud emergence on the cell cortex. The Rho-family GTPase Cdc42p and its associated proteins then establish an ... [more]
Throughput
- High Throughput
Ontology Terms
- phenotype: inviable (APO:0000112)
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| CDC42 PEA2 | Synthetic Lethality Synthetic Lethality A genetic interaction is inferred when mutations or deletions in separate genes, each of which alone causes a minimal phenotype, result in lethality when combined in the same cell under a given condition. | High | - | BioGRID | 450273 |
Curated By
- BioGRID