DMD
Gene Ontology Biological Process
- cardiac muscle cell action potential [IMP]
- cardiac muscle contraction [ISO]
- cellular protein complex assembly [IMP]
- cellular protein localization [IMP, ISO]
- establishment of blood-nerve barrier [IMP]
- establishment of glial blood-brain barrier [IMP]
- muscle cell cellular homeostasis [IMP]
- muscle fiber development [IGI]
- muscle organ development [IMP]
- myotube cell development [IMP]
- negative regulation of ERK1 and ERK2 cascade [IMP]
- negative regulation of peptidyl-cysteine S-nitrosylation [IMP]
- negative regulation of peptidyl-serine phosphorylation [IMP]
- neurotransmitter receptor metabolic process [IMP]
- nucleus localization [IMP]
- olfactory nerve structural organization [IMP]
- peptide biosynthetic process [ISO]
- positive regulation of cell-matrix adhesion [IMP]
- positive regulation of neuron differentiation [ISO]
- positive regulation of neuron projection development [ISO]
- positive regulation of sodium ion transmembrane transporter activity [IMP]
- regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion [IMP]
- regulation of cellular response to growth factor stimulus [ISO]
- regulation of gene expression [IMP]
- regulation of heart rate [IMP, ISO]
- regulation of membrane potential [IMP]
- regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum [IMP]
- regulation of ryanodine-sensitive calcium-release channel activity [IMP]
- regulation of skeletal muscle contraction [IMP]
- regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion [IMP]
- regulation of transcription, DNA-templated [IMP]
- regulation of voltage-gated calcium channel activity [IMP]
- response to muscle stretch [IMP]
- skeletal muscle tissue development [IGI, IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- Z disc [IDA]
- cell [IMP]
- cell surface [ISO]
- cell-substrate junction [IDA]
- costamere [ISO]
- dystrophin-associated glycoprotein complex [IDA, ISO]
- filopodium [ISO]
- filopodium membrane [ISO]
- intracellular [IMP]
- membrane raft [IDA]
- neuron projection terminus [IDA]
- nucleus [ISO]
- plasma membrane [IDA]
- protein complex [ISO]
- sarcolemma [IDA, ISO]
- synapse [IDA]
NOS1
Gene Ontology Biological Process
- arginine catabolic process [ISO]
- behavioral response to cocaine [ISO]
- cellular response to epinephrine stimulus [ISO]
- cellular response to growth factor stimulus [IMP]
- cellular response to mechanical stimulus [ISO]
- exogenous drug catabolic process [IMP]
- multicellular organismal response to stress [ISO]
- negative regulation of apoptotic process [ISO]
- negative regulation of blood pressure [IBA, ISO]
- negative regulation of calcium ion transport [IMP]
- negative regulation of cell proliferation [ISO]
- negative regulation of cytosolic calcium ion concentration [ISO]
- negative regulation of heart contraction [ISO]
- negative regulation of hydrolase activity [IMP]
- negative regulation of insulin secretion [ISO]
- negative regulation of peptidyl-serine phosphorylation [ISO]
- negative regulation of potassium ion transport [IMP]
- negative regulation of serotonin uptake [IDA]
- negative regulation of vasoconstriction [ISO]
- nitric oxide biosynthetic process [IDA, ISO]
- nitric oxide mediated signal transduction [IBA, ISO]
- oxidation-reduction process [IBA]
- peptidyl-cysteine S-nitrosylation [IDA, ISO]
- positive regulation of adrenergic receptor signaling pathway involved in heart process [IMP]
- positive regulation of guanylate cyclase activity [IBA]
- positive regulation of histone acetylation [IMP]
- positive regulation of long-term synaptic potentiation [ISO]
- positive regulation of neuron death [ISO]
- positive regulation of sodium ion transmembrane transport [ISO]
- positive regulation of the force of heart contraction [IMP]
- positive regulation of transcription from RNA polymerase II promoter [IMP]
- positive regulation of transcription, DNA-templated [IMP]
- positive regulation of vasodilation [IBA, ISO]
- regulation of heart contraction [ISO]
- regulation of sensory perception of pain [ISO]
- regulation of sodium ion transport [IMP]
- response to estrogen [ISO]
- response to heat [ISO]
- response to peptide hormone [ISO]
- striated muscle contraction [IMP]
Gene Ontology Molecular Function- ATPase binding [ISO]
- FMN binding [ISO]
- NADP binding [ISO]
- NADPH-hemoprotein reductase activity [IBA]
- cadmium ion binding [ISO]
- calmodulin binding [ISO]
- enzyme binding [ISO]
- flavin adenine dinucleotide binding [ISO]
- heme binding [ISO]
- ion channel binding [ISO]
- nitric-oxide synthase activity [IDA, ISO]
- protein binding [IPI]
- protein homodimerization activity [ISO]
- scaffold protein binding [ISO]
- sodium channel regulator activity [ISO]
- ATPase binding [ISO]
- FMN binding [ISO]
- NADP binding [ISO]
- NADPH-hemoprotein reductase activity [IBA]
- cadmium ion binding [ISO]
- calmodulin binding [ISO]
- enzyme binding [ISO]
- flavin adenine dinucleotide binding [ISO]
- heme binding [ISO]
- ion channel binding [ISO]
- nitric-oxide synthase activity [IDA, ISO]
- protein binding [IPI]
- protein homodimerization activity [ISO]
- scaffold protein binding [ISO]
- sodium channel regulator activity [ISO]
Gene Ontology Cellular Component
- azurophil granule [ISO]
- cytoplasm [ISO]
- cytoskeleton [IDA]
- cytosol [IBA, ISO]
- dendrite [ISO]
- membrane [ISO]
- membrane raft [IDA]
- mitochondrial outer membrane [ISO]
- mitochondrion [ISO]
- nuclear membrane [ISO]
- nucleus [ISO]
- perinuclear region of cytoplasm [ISO]
- photoreceptor inner segment [ISO]
- plasma membrane [ISO]
- postsynaptic density [ISO]
- protein complex [ISO]
- sarcolemma [IDA, ISO]
- sarcoplasmic reticulum [ISO]
- synapse [IDA, ISO]
- vesicle membrane [ISO]
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Proteomic analysis reveals new cardiac-specific dystrophin-associated proteins.
Mutations affecting the expression of dystrophin result in progressive loss of skeletal muscle function and cardiomyopathy leading to early mortality. Interestingly, clinical studies revealed no correlation in disease severity or age of onset between cardiac and skeletal muscles, suggesting that dystrophin may play overlapping yet different roles in these two striated muscles. Since dystrophin serves as a structural and signaling ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| DMD NOS1 | Co-fractionation Co-fractionation Interaction inferred from the presence of two or more protein subunits in a partially purified protein preparation. If co-fractionation is demonstrated between 3 or more proteins, then add them as a complex. | High | 0.754 | BioGRID | 2683133 | |
| NOS1 DMD | Reconstituted Complex Reconstituted Complex An interaction is inferred between proteins in vitro. This can include proteins in recombinant form or proteins isolated directly from cells with recombinant or purified bait. For example, GST pull-down assays where a GST-tagged protein is first isolated and then used to fish interactors from cell lysates are considered reconstituted complexes (e.g. PUBMED: 14657240, Fig. 4A or PUBMED: 14761940, Fig. 5). This can also include gel-shifts, surface plasmon resonance, isothermal titration calorimetry (ITC) and bio-layer interferometry (BLI) experiments. The bait-hit directionality may not be clear for 2 interacting proteins. In these cases the directionality is up to the discretion of the curator. | Low | - | BioGRID | - | |
| DMD NOS1 | Reconstituted Complex Reconstituted Complex An interaction is inferred between proteins in vitro. This can include proteins in recombinant form or proteins isolated directly from cells with recombinant or purified bait. For example, GST pull-down assays where a GST-tagged protein is first isolated and then used to fish interactors from cell lysates are considered reconstituted complexes (e.g. PUBMED: 14657240, Fig. 4A or PUBMED: 14761940, Fig. 5). This can also include gel-shifts, surface plasmon resonance, isothermal titration calorimetry (ITC) and bio-layer interferometry (BLI) experiments. The bait-hit directionality may not be clear for 2 interacting proteins. In these cases the directionality is up to the discretion of the curator. | Low | - | BioGRID | - |
Curated By
- BioGRID