BAIT
DMD
DXSmh7, DXSmh9, Dp427, Dp71, dys, mdx, pke, RP23-58B9.1
dystrophin, muscular dystrophy
GO Process (34)
GO Function (7)
GO Component (16)
Gene Ontology Biological Process
- cardiac muscle cell action potential [IMP]
- cardiac muscle contraction [ISO]
- cellular protein complex assembly [IMP]
- cellular protein localization [IMP, ISO]
- establishment of blood-nerve barrier [IMP]
- establishment of glial blood-brain barrier [IMP]
- muscle cell cellular homeostasis [IMP]
- muscle fiber development [IGI]
- muscle organ development [IMP]
- myotube cell development [IMP]
- negative regulation of ERK1 and ERK2 cascade [IMP]
- negative regulation of peptidyl-cysteine S-nitrosylation [IMP]
- negative regulation of peptidyl-serine phosphorylation [IMP]
- neurotransmitter receptor metabolic process [IMP]
- nucleus localization [IMP]
- olfactory nerve structural organization [IMP]
- peptide biosynthetic process [ISO]
- positive regulation of cell-matrix adhesion [IMP]
- positive regulation of neuron differentiation [ISO]
- positive regulation of neuron projection development [ISO]
- positive regulation of sodium ion transmembrane transporter activity [IMP]
- regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion [IMP]
- regulation of cellular response to growth factor stimulus [ISO]
- regulation of gene expression [IMP]
- regulation of heart rate [IMP, ISO]
- regulation of membrane potential [IMP]
- regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum [IMP]
- regulation of ryanodine-sensitive calcium-release channel activity [IMP]
- regulation of skeletal muscle contraction [IMP]
- regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion [IMP]
- regulation of transcription, DNA-templated [IMP]
- regulation of voltage-gated calcium channel activity [IMP]
- response to muscle stretch [IMP]
- skeletal muscle tissue development [IGI, IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- Z disc [IDA]
- cell [IMP]
- cell surface [ISO]
- cell-substrate junction [IDA]
- costamere [ISO]
- dystrophin-associated glycoprotein complex [IDA, ISO]
- filopodium [ISO]
- filopodium membrane [ISO]
- intracellular [IMP]
- membrane raft [IDA]
- neuron projection terminus [IDA]
- nucleus [ISO]
- plasma membrane [IDA]
- protein complex [ISO]
- sarcolemma [IDA, ISO]
- synapse [IDA]
Mus musculus
PREY
SGCD
35kDa, delta-SG, RP23-43C21.1
sarcoglycan, delta (dystrophin-associated glycoprotein)
GO Process (5)
GO Function (1)
GO Component (5)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Proteomic analysis reveals new cardiac-specific dystrophin-associated proteins.
Mutations affecting the expression of dystrophin result in progressive loss of skeletal muscle function and cardiomyopathy leading to early mortality. Interestingly, clinical studies revealed no correlation in disease severity or age of onset between cardiac and skeletal muscles, suggesting that dystrophin may play overlapping yet different roles in these two striated muscles. Since dystrophin serves as a structural and signaling ... [more]
PLoS ONE Sep. 01, 2012; 7(8);e43515 [Pubmed: 22937058]
Throughput
- Low Throughput
Curated By
- BioGRID