BAIT
ESR2
ER-BETA, ESR-BETA, ESRB, ESTRB, Erb, NR3A2
estrogen receptor 2 (ER beta)
GO Process (10)
GO Function (12)
GO Component (4)
Gene Ontology Biological Process
- cell-cell signaling [TAS]
- extracellular negative regulation of signal transduction [NAS]
- gene expression [TAS]
- intracellular estrogen receptor signaling pathway [TAS]
- negative regulation of cell growth [NAS]
- negative regulation of transcription from RNA polymerase II promoter [IDA]
- positive regulation of sequence-specific DNA binding transcription factor activity [IDA]
- regulation of transcription, DNA-templated [TAS]
- signal transduction [TAS]
- transcription initiation from RNA polymerase II promoter [TAS]
Gene Ontology Molecular Function- DNA binding [TAS]
- core promoter sequence-specific DNA binding [IDA]
- enzyme binding [IPI]
- estrogen receptor activity [TAS]
- estrogen response element binding [IDA]
- ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity [IDA, NAS]
- protein binding [IPI]
- receptor antagonist activity [NAS]
- sequence-specific DNA binding transcription factor activity [TAS]
- steroid binding [ISS, TAS]
- steroid hormone receptor activity [TAS]
- transcription coactivator activity [TAS]
- DNA binding [TAS]
- core promoter sequence-specific DNA binding [IDA]
- enzyme binding [IPI]
- estrogen receptor activity [TAS]
- estrogen response element binding [IDA]
- ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity [IDA, NAS]
- protein binding [IPI]
- receptor antagonist activity [NAS]
- sequence-specific DNA binding transcription factor activity [TAS]
- steroid binding [ISS, TAS]
- steroid hormone receptor activity [TAS]
- transcription coactivator activity [TAS]
Gene Ontology Cellular Component
Homo sapiens
PREY
SRA1
SRA, SRAP, STRAA1, PP7684
steroid receptor RNA activator 1
GO Process (4)
GO Function (3)
GO Component (7)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Far Western
An interaction is detected between a protein immobilized on a membrane and a purified protein probe.
Publication
The steroid receptor RNA activator protein is recruited to promoter regions and acts as a transcriptional repressor.
Products of the steroid receptor RNA activator (SRA1) gene have the unusual property to function both at the RNA and the protein levels. SRA-RNA has long been known to increase the activity of multiple nuclear receptors. It has more recently been proposed than steroid receptor RNA activator protein (SRAP) also modulates steroid receptors activity. Herein, we show for the first ... [more]
FEBS Lett. Jun. 03, 2010; 584(11);2218-24 [Pubmed: 20398657]
Throughput
- Low Throughput
Additional Notes
- figure 1, table 1.
Curated By
- BioGRID