BAIT
FOXP3
JM2, scurfin, sf, RP23-54C14.1
forkhead box P3
GO Process (52)
GO Function (8)
GO Component (3)
Gene Ontology Biological Process
- B cell homeostasis [IMP]
- CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation [IMP]
- T cell activation [IMP, ISO]
- T cell mediated immunity [IMP]
- T cell receptor signaling pathway [IMP]
- cytokine production [IDA, IGI, IMP]
- myeloid cell homeostasis [IMP]
- negative regulation of CREB transcription factor activity [ISO]
- negative regulation of NF-kappaB transcription factor activity [ISO]
- negative regulation of T cell cytokine production [ISO]
- negative regulation of T cell proliferation [IDA, IMP, ISO]
- negative regulation of cell proliferation [ISO]
- negative regulation of chronic inflammatory response [IDA, IMP]
- negative regulation of cytokine biosynthetic process [ISO]
- negative regulation of cytokine secretion [ISO]
- negative regulation of histone acetylation [IDA]
- negative regulation of histone deacetylation [ISO]
- negative regulation of immune response [ISO]
- negative regulation of inflammatory response [IMP]
- negative regulation of interferon-gamma biosynthetic process [IDA]
- negative regulation of interferon-gamma production [IDA, IMP, ISO]
- negative regulation of interleukin-10 production [IMP, ISO]
- negative regulation of interleukin-2 biosynthetic process [IDA, ISO]
- negative regulation of interleukin-2 production [IDA, ISO]
- negative regulation of interleukin-4 production [IDA, IMP, ISO]
- negative regulation of interleukin-5 production [IDA, IMP]
- negative regulation of interleukin-6 production [IMP]
- negative regulation of isotype switching to IgE isotypes [IMP]
- negative regulation of lymphocyte proliferation [IMP]
- negative regulation of sequence-specific DNA binding transcription factor activity [ISO]
- negative regulation of transcription from RNA polymerase II promoter [IDA, IMP]
- negative regulation of transcription, DNA-templated [IDA, ISO]
- negative regulation of tumor necrosis factor production [IMP]
- positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation [IMP]
- positive regulation of T cell anergy [IMP]
- positive regulation of T cell tolerance induction [IMP]
- positive regulation of gene expression [IDA]
- positive regulation of histone acetylation [IDA, ISO]
- positive regulation of immature T cell proliferation in thymus [IMP]
- positive regulation of interleukin-4 production [IMP]
- positive regulation of peripheral T cell tolerance induction [IMP]
- positive regulation of regulatory T cell differentiation [IDA]
- positive regulation of transcription from RNA polymerase II promoter [IDA, IMP, ISO]
- positive regulation of transcription, DNA-templated [IDA, ISO]
- positive regulation of transforming growth factor beta1 production [IDA]
- regulation of immunoglobulin production [IMP]
- regulation of isotype switching to IgG isotypes [IMP]
- regulation of transcription from RNA polymerase II promoter [IGI]
- regulatory T cell differentiation [IDA, IMP]
- tolerance induction [IDA]
- tolerance induction to self antigen [IMP]
- transcription from RNA polymerase II promoter [IDA]
Gene Ontology Molecular Function- NFAT protein binding [ISO]
- RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity [IDA]
- histone acetyltransferase binding [ISO]
- histone deacetylase binding [ISO]
- protein homodimerization activity [IDA, ISO]
- sequence-specific DNA binding [IDA, ISO]
- sequence-specific DNA binding transcription factor activity [IDA, ISO]
- transcription corepressor activity [IDA]
- NFAT protein binding [ISO]
- RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity [IDA]
- histone acetyltransferase binding [ISO]
- histone deacetylase binding [ISO]
- protein homodimerization activity [IDA, ISO]
- sequence-specific DNA binding [IDA, ISO]
- sequence-specific DNA binding transcription factor activity [IDA, ISO]
- transcription corepressor activity [IDA]
Mus musculus
PREY
CSE1L
2610100P18Rik, AA407533, Capts, Cas, Xpo2, RP23-19L12.9
chromosome segregation 1-like (S. cerevisiae)
GO Process (0)
GO Function (1)
GO Component (4)
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Transcription factor Foxp3 and its protein partners form a complex regulatory network.
The transcription factor Foxp3 is indispensible for the differentiation and function of regulatory T cells (T(reg) cells). To gain insights into the molecular mechanisms of Foxp3-mediated gene expression, we purified Foxp3 complexes and explored their composition. Biochemical and mass-spectrometric analyses revealed that Foxp3 forms multiprotein complexes of 400-800 kDa or larger and identified 361 associated proteins, ∼30% of which were ... [more]
Nat. Immunol. Oct. 01, 2012; 13(10);1010-9 [Pubmed: 22922362]
Throughput
- High Throughput
Curated By
- BioGRID