BAIT
FOXP3
JM2, scurfin, sf, RP23-54C14.1
forkhead box P3
GO Process (52)
GO Function (8)
GO Component (3)
Gene Ontology Biological Process
- B cell homeostasis [IMP]
- CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation [IMP]
- T cell activation [IMP, ISO]
- T cell mediated immunity [IMP]
- T cell receptor signaling pathway [IMP]
- cytokine production [IDA, IGI, IMP]
- myeloid cell homeostasis [IMP]
- negative regulation of CREB transcription factor activity [ISO]
- negative regulation of NF-kappaB transcription factor activity [ISO]
- negative regulation of T cell cytokine production [ISO]
- negative regulation of T cell proliferation [IDA, IMP, ISO]
- negative regulation of cell proliferation [ISO]
- negative regulation of chronic inflammatory response [IDA, IMP]
- negative regulation of cytokine biosynthetic process [ISO]
- negative regulation of cytokine secretion [ISO]
- negative regulation of histone acetylation [IDA]
- negative regulation of histone deacetylation [ISO]
- negative regulation of immune response [ISO]
- negative regulation of inflammatory response [IMP]
- negative regulation of interferon-gamma biosynthetic process [IDA]
- negative regulation of interferon-gamma production [IDA, IMP, ISO]
- negative regulation of interleukin-10 production [IMP, ISO]
- negative regulation of interleukin-2 biosynthetic process [IDA, ISO]
- negative regulation of interleukin-2 production [IDA, ISO]
- negative regulation of interleukin-4 production [IDA, IMP, ISO]
- negative regulation of interleukin-5 production [IDA, IMP]
- negative regulation of interleukin-6 production [IMP]
- negative regulation of isotype switching to IgE isotypes [IMP]
- negative regulation of lymphocyte proliferation [IMP]
- negative regulation of sequence-specific DNA binding transcription factor activity [ISO]
- negative regulation of transcription from RNA polymerase II promoter [IDA, IMP]
- negative regulation of transcription, DNA-templated [IDA, ISO]
- negative regulation of tumor necrosis factor production [IMP]
- positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation [IMP]
- positive regulation of T cell anergy [IMP]
- positive regulation of T cell tolerance induction [IMP]
- positive regulation of gene expression [IDA]
- positive regulation of histone acetylation [IDA, ISO]
- positive regulation of immature T cell proliferation in thymus [IMP]
- positive regulation of interleukin-4 production [IMP]
- positive regulation of peripheral T cell tolerance induction [IMP]
- positive regulation of regulatory T cell differentiation [IDA]
- positive regulation of transcription from RNA polymerase II promoter [IDA, IMP, ISO]
- positive regulation of transcription, DNA-templated [IDA, ISO]
- positive regulation of transforming growth factor beta1 production [IDA]
- regulation of immunoglobulin production [IMP]
- regulation of isotype switching to IgG isotypes [IMP]
- regulation of transcription from RNA polymerase II promoter [IGI]
- regulatory T cell differentiation [IDA, IMP]
- tolerance induction [IDA]
- tolerance induction to self antigen [IMP]
- transcription from RNA polymerase II promoter [IDA]
Gene Ontology Molecular Function- NFAT protein binding [ISO]
- RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity [IDA]
- histone acetyltransferase binding [ISO]
- histone deacetylase binding [ISO]
- protein homodimerization activity [IDA, ISO]
- sequence-specific DNA binding [IDA, ISO]
- sequence-specific DNA binding transcription factor activity [IDA, ISO]
- transcription corepressor activity [IDA]
- NFAT protein binding [ISO]
- RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity [IDA]
- histone acetyltransferase binding [ISO]
- histone deacetylase binding [ISO]
- protein homodimerization activity [IDA, ISO]
- sequence-specific DNA binding [IDA, ISO]
- sequence-specific DNA binding transcription factor activity [IDA, ISO]
- transcription corepressor activity [IDA]
Mus musculus
PREY
GSK3B
7330414F15Rik, 8430431H08Rik, C86142, GSK-3, GSK-3beta, GSK3
glycogen synthase kinase 3 beta
GO Process (56)
GO Function (17)
GO Component (19)
Gene Ontology Biological Process
- ER overload response [IDA, ISO]
- Wnt signaling pathway [IGI]
- axonogenesis [IGI]
- canonical Wnt signaling pathway [IDA, ISO]
- canonical Wnt signaling pathway involved in positive regulation of apoptotic process [IMP]
- cell migration [IGI]
- cell proliferation [TAS]
- cellular response to interleukin-3 [IDA]
- cellular response to mechanical stimulus [ISO]
- circadian rhythm [IMP]
- cytoskeleton organization [TAS]
- epithelial to mesenchymal transition [ISO]
- establishment of cell polarity [ISO]
- establishment or maintenance of cell polarity [ISO]
- extrinsic apoptotic signaling pathway in absence of ligand [IDA]
- fat cell differentiation [IDA]
- glycogen metabolic process [ISO]
- hippocampus development [ISO]
- hypermethylation of CpG island [IMP]
- intracellular signal transduction [ISO]
- myoblast fusion [IDA, IGI]
- myotube differentiation [IGI]
- negative regulation of MAP kinase activity [ISO]
- negative regulation of NFAT protein import into nucleus [ISO]
- negative regulation of apoptotic process [IMP, ISO]
- negative regulation of cardiac muscle hypertrophy [IDA]
- negative regulation of dendrite morphogenesis [ISO]
- negative regulation of neuron maturation [IGI]
- negative regulation of neuron projection development [IGI, IMP]
- negative regulation of protein binding [ISO]
- negative regulation of protein complex assembly [ISO]
- organ morphogenesis [IMP]
- peptidyl-serine phosphorylation [IDA, ISO]
- phosphorylation [IMP]
- positive regulation of Rac GTPase activity [ISO]
- positive regulation of apoptotic process [ISO]
- positive regulation of axon extension [IGI]
- positive regulation of cell-matrix adhesion [ISO]
- positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway [IDA]
- positive regulation of peptidyl-serine phosphorylation [IDA]
- positive regulation of peptidyl-threonine phosphorylation [IDA]
- positive regulation of proteasomal ubiquitin-dependent protein catabolic process [IGI]
- positive regulation of protein binding [IDA]
- positive regulation of protein complex assembly [ISO]
- positive regulation of protein export from nucleus [ISO]
- positive regulation of stem cell differentiation [IMP]
- positive regulation of transcription from RNA polymerase II promoter [IMP]
- protein export from nucleus [IDA]
- protein localization to microtubule [IGI]
- protein phosphorylation [IDA, IGI, IMP, ISO, ISS]
- re-entry into mitotic cell cycle [IDA]
- regulation of gene expression by genetic imprinting [IMP]
- regulation of microtubule-based process [IDA, ISO]
- regulation of neuron projection development [IGI]
- regulation of neuronal synaptic plasticity [ISO]
- superior temporal gyrus development [ISO]
Gene Ontology Molecular Function- ATP binding [ISO]
- NF-kappaB binding [ISO]
- RNA polymerase II transcription factor binding [ISO]
- beta-catenin binding [IPI, ISO]
- integrin binding [ISO]
- ionotropic glutamate receptor binding [ISO]
- kinase activity [ISO]
- p53 binding [ISO]
- protein binding [IPI]
- protein kinase A catalytic subunit binding [ISO]
- protein kinase activity [IDA]
- protein kinase binding [ISO]
- protein serine/threonine kinase activity [IDA, IMP, ISO, ISS]
- tau protein binding [ISO]
- tau-protein kinase activity [IDA, ISO]
- transcription factor binding [ISO]
- ubiquitin protein ligase binding [ISO]
- ATP binding [ISO]
- NF-kappaB binding [ISO]
- RNA polymerase II transcription factor binding [ISO]
- beta-catenin binding [IPI, ISO]
- integrin binding [ISO]
- ionotropic glutamate receptor binding [ISO]
- kinase activity [ISO]
- p53 binding [ISO]
- protein binding [IPI]
- protein kinase A catalytic subunit binding [ISO]
- protein kinase activity [IDA]
- protein kinase binding [ISO]
- protein serine/threonine kinase activity [IDA, IMP, ISO, ISS]
- tau protein binding [ISO]
- tau-protein kinase activity [IDA, ISO]
- transcription factor binding [ISO]
- ubiquitin protein ligase binding [ISO]
Gene Ontology Cellular Component
- beta-catenin destruction complex [IDA, ISO]
- cell body [IDA]
- centrosome [ISO]
- cytoplasm [ISO]
- cytosol [IDA, ISO]
- dendritic shaft [IDA]
- dendritic spine [ISO]
- growth cone [IDA]
- membrane [ISO]
- membrane raft [ISO]
- membrane-bounded organelle [IDA]
- neuronal cell body [IDA]
- neuronal postsynaptic density [IDA]
- nucleoplasm [ISO]
- nucleus [IDA, ISO]
- perinuclear region of cytoplasm [IDA]
- plasma membrane [ISO]
- protein complex [ISO]
- ribonucleoprotein complex [IDA]
Mus musculus
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Transcription factor Foxp3 and its protein partners form a complex regulatory network.
The transcription factor Foxp3 is indispensible for the differentiation and function of regulatory T cells (T(reg) cells). To gain insights into the molecular mechanisms of Foxp3-mediated gene expression, we purified Foxp3 complexes and explored their composition. Biochemical and mass-spectrometric analyses revealed that Foxp3 forms multiprotein complexes of 400-800 kDa or larger and identified 361 associated proteins, ∼30% of which were ... [more]
Nat. Immunol. Oct. 01, 2012; 13(10);1010-9 [Pubmed: 22922362]
Throughput
- High Throughput
Curated By
- BioGRID