BAIT

FOXP3

JM2, scurfin, sf, RP23-54C14.1
forkhead box P3
GO Process (52)
GO Function (8)
GO Component (3)

Gene Ontology Biological Process

Gene Ontology Cellular Component

Mus musculus
PREY

LRRC40

2610040E16Rik, AI837674
leucine rich repeat containing 40
GO Process (0)
GO Function (0)
GO Component (1)

Gene Ontology Cellular Component

Mus musculus

Affinity Capture-MS

An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.

Publication

Transcription factor Foxp3 and its protein partners form a complex regulatory network.

Rudra D, deRoos P, Chaudhry A, Niec RE, Arvey A, Samstein RM, Leslie C, Shaffer SA, Goodlett DR, Rudensky AY

The transcription factor Foxp3 is indispensible for the differentiation and function of regulatory T cells (T(reg) cells). To gain insights into the molecular mechanisms of Foxp3-mediated gene expression, we purified Foxp3 complexes and explored their composition. Biochemical and mass-spectrometric analyses revealed that Foxp3 forms multiprotein complexes of 400-800 kDa or larger and identified 361 associated proteins, ∼30% of which were ... [more]

Nat. Immunol. Oct. 01, 2012; 13(10);1010-9 [Pubmed: 22922362]

Throughput

  • High Throughput

Curated By

  • BioGRID