BAIT
NLGN1
neuroligin 1
GO Process (40)
GO Function (7)
GO Component (9)
Gene Ontology Biological Process
- N-methyl-D-aspartate receptor clustering [IDA]
- alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor clustering [IMP, ISO, ISS]
- calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules [IDA, ISO]
- cytoskeletal matrix organization at active zone [IMP, ISO]
- establishment of protein localization [ISO, ISS]
- heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules [ISO, ISS]
- metabolic process [IBA]
- nervous system development [ISO, ISS]
- neurexin clustering [ISO, ISS]
- neuron cell-cell adhesion [IDA, ISO]
- neuronal ion channel clustering [TAS]
- positive regulation of dendritic spine development [IDA]
- positive regulation of excitatory postsynaptic membrane potential [IDA, IMP, ISO]
- positive regulation of filopodium assembly [IDA]
- positive regulation of intracellular signal transduction [IDA]
- positive regulation of ruffle assembly [IDA]
- positive regulation of synapse assembly [IDA, ISO]
- positive regulation of synaptic transmission, GABAergic [IDA]
- positive regulation of synaptic transmission, glutamatergic [IDA, IMP]
- positive regulation of synaptic vesicle endocytosis [IMP, ISO]
- positive regulation of synaptic vesicle exocytosis [IMP, ISO]
- postsynaptic density protein 95 clustering [IDA, ISO, ISS]
- postsynaptic membrane assembly [ISO, ISS]
- presynaptic membrane assembly [IDA, ISO]
- protein heterotetramerization [IDA]
- protein homooligomerization [ISO, ISS]
- protein localization to synapse [ISO, ISS]
- protein targeting [IDA]
- receptor localization to synapse [ISO, ISS]
- regulation of N-methyl-D-aspartate selective glutamate receptor activity [IDA, IMP, ISO]
- regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity [IDA]
- regulation of inhibitory postsynaptic membrane potential [IDA, ISO]
- regulation of neuron differentiation [ISO, ISS]
- regulation of respiratory gaseous exchange by neurological system process [ISO]
- regulation of synaptic transmission [ISO]
- synapse assembly [IDA, ISO, ISS]
- synapse organization [IDA, ISO]
- synaptic vesicle clustering [IMP, ISO, ISS]
- synaptic vesicle targeting [ISO, ISS]
- terminal button organization [IMP, ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Rattus norvegicus
PREY
SHANK1
Shank1a, Spank1, Sstrip
SH3 and multiple ankyrin repeat domains 1
GO Process (19)
GO Function (11)
GO Component (12)
Gene Ontology Biological Process
- adult behavior [ISO]
- associative learning [ISO, ISS]
- cytoskeletal anchoring at plasma membrane [NAS]
- dendritic spine morphogenesis [ISO, ISS]
- determination of affect [ISO]
- habituation [ISO, ISS]
- long-term memory [ISO, ISS]
- negative regulation of actin filament bundle assembly [ISO, ISS]
- neuromuscular process controlling balance [ISO, ISS]
- olfactory behavior [ISO, ISS]
- positive regulation of dendritic spine development [IDA]
- positive regulation of excitatory postsynaptic membrane potential [ISO, ISS]
- protein complex assembly [IDA]
- protein localization to synapse [ISO, ISS]
- regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity [ISO, ISS]
- righting reflex [ISO, ISS]
- social behavior [ISO]
- synapse maturation [IDA]
- vocalization behavior [ISO]
Gene Ontology Molecular Function- GKAP/Homer scaffold activity [IDA, ISO]
- SH3 domain binding [IPI]
- ankyrin repeat binding [IPI]
- identical protein binding [IPI]
- ionotropic glutamate receptor binding [IPI, ISO]
- protein C-terminus binding [IPI]
- protein binding [IPI]
- protein complex binding [IPI]
- receptor signaling complex scaffold activity [IDA]
- scaffold protein binding [IPI]
- somatostatin receptor binding [IPI]
- GKAP/Homer scaffold activity [IDA, ISO]
- SH3 domain binding [IPI]
- ankyrin repeat binding [IPI]
- identical protein binding [IPI]
- ionotropic glutamate receptor binding [IPI, ISO]
- protein C-terminus binding [IPI]
- protein binding [IPI]
- protein complex binding [IPI]
- receptor signaling complex scaffold activity [IDA]
- scaffold protein binding [IPI]
- somatostatin receptor binding [IPI]
Gene Ontology Cellular Component
- N-methyl-D-aspartate selective glutamate receptor complex [IDA]
- dendrite [ISO, NAS]
- dendritic spine [IDA, ISO]
- excitatory synapse [ISO, ISS]
- intracellular [NAS]
- ionotropic glutamate receptor complex [ISO, ISS]
- membrane [ISO]
- neuron projection [ISO, ISS]
- neuronal postsynaptic density [ISO, ISS]
- plasma membrane [ISO, ISS]
- postsynaptic membrane [IDA, ISO]
- synapse [IDA]
Rattus norvegicus
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
The complexity of PDZ domain-mediated interactions at glutamatergic synapses: a case study on neuroligin.
The postsynaptic specialisation at glutamatergic synapses is composed of a network of proteins located within the membrane and the underlying postsynaptic density. The strong interconnectivity between the protein components is mediated by a limited number of interaction modes. Particularly abundant are PDZ domain-mediated interactions. An obstacle in understanding the fidelity of postsynaptic processes involving PDZ domains is the high degree ... [more]
Neuropharmacology Oct. 01, 2004; 47(5);724-33 [Pubmed: 15458844]
Throughput
- Low Throughput
Curated By
- BioGRID