BAIT

NLGN1

neuroligin 1
GO Process (40)
GO Function (7)
GO Component (9)

Gene Ontology Biological Process

Rattus norvegicus
PREY

SHANK1

Shank1a, Spank1, Sstrip
SH3 and multiple ankyrin repeat domains 1
GO Process (19)
GO Function (11)
GO Component (12)
Rattus norvegicus

Two-hybrid

Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.

Publication

The complexity of PDZ domain-mediated interactions at glutamatergic synapses: a case study on neuroligin.

Meyer G, Varoqueaux F, Neeb A, Oschlies M, Brose N

The postsynaptic specialisation at glutamatergic synapses is composed of a network of proteins located within the membrane and the underlying postsynaptic density. The strong interconnectivity between the protein components is mediated by a limited number of interaction modes. Particularly abundant are PDZ domain-mediated interactions. An obstacle in understanding the fidelity of postsynaptic processes involving PDZ domains is the high degree ... [more]

Neuropharmacology Oct. 01, 2004; 47(5);724-33 [Pubmed: 15458844]

Throughput

  • Low Throughput

Curated By

  • BioGRID