BAIT
NLGN1
neuroligin 1
GO Process (40)
GO Function (7)
GO Component (9)
Gene Ontology Biological Process
- N-methyl-D-aspartate receptor clustering [IDA]
- alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor clustering [IMP, ISO, ISS]
- calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules [IDA, ISO]
- cytoskeletal matrix organization at active zone [IMP, ISO]
- establishment of protein localization [ISO, ISS]
- heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules [ISO, ISS]
- metabolic process [IBA]
- nervous system development [ISO, ISS]
- neurexin clustering [ISO, ISS]
- neuron cell-cell adhesion [IDA, ISO]
- neuronal ion channel clustering [TAS]
- positive regulation of dendritic spine development [IDA]
- positive regulation of excitatory postsynaptic membrane potential [IDA, IMP, ISO]
- positive regulation of filopodium assembly [IDA]
- positive regulation of intracellular signal transduction [IDA]
- positive regulation of ruffle assembly [IDA]
- positive regulation of synapse assembly [IDA, ISO]
- positive regulation of synaptic transmission, GABAergic [IDA]
- positive regulation of synaptic transmission, glutamatergic [IDA, IMP]
- positive regulation of synaptic vesicle endocytosis [IMP, ISO]
- positive regulation of synaptic vesicle exocytosis [IMP, ISO]
- postsynaptic density protein 95 clustering [IDA, ISO, ISS]
- postsynaptic membrane assembly [ISO, ISS]
- presynaptic membrane assembly [IDA, ISO]
- protein heterotetramerization [IDA]
- protein homooligomerization [ISO, ISS]
- protein localization to synapse [ISO, ISS]
- protein targeting [IDA]
- receptor localization to synapse [ISO, ISS]
- regulation of N-methyl-D-aspartate selective glutamate receptor activity [IDA, IMP, ISO]
- regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity [IDA]
- regulation of inhibitory postsynaptic membrane potential [IDA, ISO]
- regulation of neuron differentiation [ISO, ISS]
- regulation of respiratory gaseous exchange by neurological system process [ISO]
- regulation of synaptic transmission [ISO]
- synapse assembly [IDA, ISO, ISS]
- synapse organization [IDA, ISO]
- synaptic vesicle clustering [IMP, ISO, ISS]
- synaptic vesicle targeting [ISO, ISS]
- terminal button organization [IMP, ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Rattus norvegicus
PREY
PICK1
Prkcabp
protein interacting with PRKCA 1
GO Process (17)
GO Function (15)
GO Component (12)
Gene Ontology Biological Process
- ATP catabolic process [ISO, ISS]
- cellular response to decreased oxygen levels [IMP]
- cellular response to glucose starvation [IMP]
- dendritic spine maintenance [IMP]
- dendritic spine organization [IDA]
- dopamine transport [NAS]
- glial cell development [IMP]
- long term synaptic depression [IDA]
- monoamine transport [ISO, ISS]
- negative regulation of Arp2/3 complex-mediated actin nucleation [IDA]
- negative regulation of cell death [IDA]
- negative regulation of gene expression [IMP]
- positive regulation of receptor internalization [IDA]
- protein kinase C-activating G-protein coupled receptor signaling pathway [ISO, ISS]
- protein phosphorylation [IDA]
- protein targeting [ISO]
- receptor clustering [IMP, ISO, ISS]
Gene Ontology Molecular Function- ATPase activity [ISO, ISS]
- Arp2/3 complex binding [IDA]
- G-protein coupled glutamate receptor binding [TAS]
- G-protein coupled receptor binding [IPI, TAS]
- GTPase binding [TAS]
- actin filament binding [IDA]
- enzyme binding [ISO]
- ephrin receptor binding [TAS]
- identical protein binding [IDA]
- protein C-terminus binding [IPI, ISO, ISS]
- protein binding [IPI]
- protein domain specific binding [IMP]
- protein kinase C binding [IDA, ISO, ISS]
- receptor binding [IPI, ISO, ISS]
- receptor tyrosine kinase binding [TAS]
- ATPase activity [ISO, ISS]
- Arp2/3 complex binding [IDA]
- G-protein coupled glutamate receptor binding [TAS]
- G-protein coupled receptor binding [IPI, TAS]
- GTPase binding [TAS]
- actin filament binding [IDA]
- enzyme binding [ISO]
- ephrin receptor binding [TAS]
- identical protein binding [IDA]
- protein C-terminus binding [IPI, ISO, ISS]
- protein binding [IPI]
- protein domain specific binding [IMP]
- protein kinase C binding [IDA, ISO, ISS]
- receptor binding [IPI, ISO, ISS]
- receptor tyrosine kinase binding [TAS]
Gene Ontology Cellular Component
- Golgi apparatus [ISO, ISS]
- cytoplasm [ISO, ISS]
- dendrite [IDA]
- mitochondrion [ISO]
- neuron projection [IDA]
- neuronal postsynaptic density [ISO]
- perinuclear region of cytoplasm [IDA, ISO, ISS]
- plasma membrane [ISO, ISS]
- postsynaptic density [IDA]
- presynaptic membrane [ISO, ISS]
- protein complex [IDA]
- synapse [IDA, ISO, ISS]
Rattus norvegicus
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
The complexity of PDZ domain-mediated interactions at glutamatergic synapses: a case study on neuroligin.
The postsynaptic specialisation at glutamatergic synapses is composed of a network of proteins located within the membrane and the underlying postsynaptic density. The strong interconnectivity between the protein components is mediated by a limited number of interaction modes. Particularly abundant are PDZ domain-mediated interactions. An obstacle in understanding the fidelity of postsynaptic processes involving PDZ domains is the high degree ... [more]
Neuropharmacology Oct. 01, 2004; 47(5);724-33 [Pubmed: 15458844]
Throughput
- Low Throughput
Curated By
- BioGRID