BAIT
NLGN2
neuroligin 2
GO Process (24)
GO Function (4)
GO Component (6)
Gene Ontology Biological Process
- gephyrin clustering [ISO, ISS]
- jump response [IMP]
- locomotory exploration behavior [ISO, ISS]
- metabolic process [IBA]
- neuromuscular process controlling balance [ISO, ISS]
- neuron cell-cell adhesion [IDA]
- positive regulation of excitatory postsynaptic membrane potential [ISO, ISS]
- positive regulation of inhibitory postsynaptic membrane potential [IMP, ISO]
- positive regulation of synapse assembly [IDA]
- positive regulation of synaptic transmission, GABAergic [ISO, ISS]
- positive regulation of synaptic transmission, glutamatergic [ISO, ISS]
- postsynaptic density protein 95 clustering [ISO, ISS]
- postsynaptic membrane assembly [ISO, ISS]
- presynaptic membrane assembly [IDA, ISO]
- protein localization to synapse [ISO, ISS]
- regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity [ISO, ISS]
- regulation of respiratory gaseous exchange by neurological system process [ISO, ISS]
- regulation of synaptic transmission [IBA, ISO, ISS]
- sensory perception of pain [ISO, ISS]
- social behavior [IMP]
- synapse assembly [IDA]
- synapse organization [IDA]
- terminal button organization [IMP]
- thigmotaxis [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Rattus norvegicus
PREY
MAGI2
Acvrinp1, Acvrip1, S-SCAM
membrane associated guanylate kinase, WW and PDZ domain containing 2
GO Process (17)
GO Function (9)
GO Component (11)
Gene Ontology Biological Process
- SMAD protein signal transduction [ISO, ISS]
- cellular response to nerve growth factor stimulus [IDA]
- cytoplasmic transport [IMP]
- glomerular filtration [IC]
- glomerular visceral epithelial cell development [IEP]
- mitotic cell cycle arrest [IDA]
- negative regulation of activin receptor signaling pathway [ISO, ISS]
- negative regulation of cell migration [IDA]
- negative regulation of cell proliferation [IDA]
- negative regulation of protein kinase B signaling [ISO, ISS]
- nerve growth factor signaling pathway [IDA]
- positive regulation of neuron projection development [IMP]
- positive regulation of phosphoprotein phosphatase activity [ISO, ISS]
- positive regulation of receptor internalization [ISO, ISS]
- protein heterooligomerization [IDA]
- receptor clustering [IDA]
- signal transduction [ISO]
Gene Ontology Molecular Function- PDZ domain binding [IPI]
- SMAD binding [ISO, ISS]
- beta-1 adrenergic receptor binding [ISO, ISS]
- phosphatase binding [ISO, ISS]
- protein binding [IPI]
- protein complex binding [IPI]
- receptor signaling complex scaffold activity [ISO, ISS]
- signal transducer activity [ISO, ISS]
- type II activin receptor binding [ISO, ISS]
- PDZ domain binding [IPI]
- SMAD binding [ISO, ISS]
- beta-1 adrenergic receptor binding [ISO, ISS]
- phosphatase binding [ISO, ISS]
- protein binding [IPI]
- protein complex binding [IPI]
- receptor signaling complex scaffold activity [ISO, ISS]
- signal transducer activity [ISO, ISS]
- type II activin receptor binding [ISO, ISS]
Gene Ontology Cellular Component
Rattus norvegicus
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
The complexity of PDZ domain-mediated interactions at glutamatergic synapses: a case study on neuroligin.
The postsynaptic specialisation at glutamatergic synapses is composed of a network of proteins located within the membrane and the underlying postsynaptic density. The strong interconnectivity between the protein components is mediated by a limited number of interaction modes. Particularly abundant are PDZ domain-mediated interactions. An obstacle in understanding the fidelity of postsynaptic processes involving PDZ domains is the high degree ... [more]
Neuropharmacology Oct. 01, 2004; 47(5);724-33 [Pubmed: 15458844]
Throughput
- Low Throughput
Curated By
- BioGRID