BAIT
NLGN2
neuroligin 2
GO Process (24)
GO Function (4)
GO Component (6)
Gene Ontology Biological Process
- gephyrin clustering [ISO, ISS]
- jump response [IMP]
- locomotory exploration behavior [ISO, ISS]
- metabolic process [IBA]
- neuromuscular process controlling balance [ISO, ISS]
- neuron cell-cell adhesion [IDA]
- positive regulation of excitatory postsynaptic membrane potential [ISO, ISS]
- positive regulation of inhibitory postsynaptic membrane potential [IMP, ISO]
- positive regulation of synapse assembly [IDA]
- positive regulation of synaptic transmission, GABAergic [ISO, ISS]
- positive regulation of synaptic transmission, glutamatergic [ISO, ISS]
- postsynaptic density protein 95 clustering [ISO, ISS]
- postsynaptic membrane assembly [ISO, ISS]
- presynaptic membrane assembly [IDA, ISO]
- protein localization to synapse [ISO, ISS]
- regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity [ISO, ISS]
- regulation of respiratory gaseous exchange by neurological system process [ISO, ISS]
- regulation of synaptic transmission [IBA, ISO, ISS]
- sensory perception of pain [ISO, ISS]
- social behavior [IMP]
- synapse assembly [IDA]
- synapse organization [IDA]
- terminal button organization [IMP]
- thigmotaxis [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Rattus norvegicus
PREY
SIPA1L1
SPAL, Spa-1, Spa1, Spar
signal-induced proliferation-associated 1 like 1
GO Process (8)
GO Function (7)
GO Component (4)
Gene Ontology Biological Process
- actin cytoskeleton reorganization [IDA]
- activation of Rap GTPase activity [IDA]
- ephrin receptor signaling pathway [ISO, ISS]
- regulation of Rap GTPase activity [IDA, ISO, ISS]
- regulation of axonogenesis [ISO, ISS]
- regulation of dendrite morphogenesis [IMP]
- regulation of dendritic spine morphogenesis [IDA]
- regulation of synaptic plasticity [IDA, IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Rattus norvegicus
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
The complexity of PDZ domain-mediated interactions at glutamatergic synapses: a case study on neuroligin.
The postsynaptic specialisation at glutamatergic synapses is composed of a network of proteins located within the membrane and the underlying postsynaptic density. The strong interconnectivity between the protein components is mediated by a limited number of interaction modes. Particularly abundant are PDZ domain-mediated interactions. An obstacle in understanding the fidelity of postsynaptic processes involving PDZ domains is the high degree ... [more]
Neuropharmacology Oct. 01, 2004; 47(5);724-33 [Pubmed: 15458844]
Throughput
- Low Throughput
Curated By
- BioGRID