BAIT
GRIA2
GluA2, GluR-K2, GluR2, gluR-B
glutamate receptor, ionotropic, AMPA 2
GO Process (11)
GO Function (10)
GO Component (23)
Gene Ontology Biological Process
- establishment of protein localization [IMP]
- ion transmembrane transport [IBA]
- ionotropic glutamate receptor signaling pathway [IBA, ISO, ISS]
- positive regulation of synaptic transmission [IMP]
- protein tetramerization [IDA]
- receptor internalization [IDA]
- regulation of receptor recycling [IMP]
- regulation of synaptic transmission, glutamatergic [IMP]
- response to fungicide [IEP]
- response to lithium ion [IEP]
- synaptic transmission [IDA, ISO]
Gene Ontology Molecular Function- PDZ domain binding [IDA, IPI]
- alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity [IDA, TAS]
- calcium channel regulator activity [TAS]
- extracellular-glutamate-gated ion channel activity [IBA, ISO]
- identical protein binding [IPI]
- ionotropic glutamate receptor activity [IDA, ISO, TAS]
- kainate selective glutamate receptor activity [IDA]
- protein binding [IPI]
- protein kinase binding [IPI]
- receptor activity [IDA]
- PDZ domain binding [IDA, IPI]
- alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity [IDA, TAS]
- calcium channel regulator activity [TAS]
- extracellular-glutamate-gated ion channel activity [IBA, ISO]
- identical protein binding [IPI]
- ionotropic glutamate receptor activity [IDA, ISO, TAS]
- kainate selective glutamate receptor activity [IDA]
- protein binding [IPI]
- protein kinase binding [IPI]
- receptor activity [IDA]
Gene Ontology Cellular Component
- alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex [IDA, ISO]
- asymmetric synapse [IDA]
- cell surface [IDA]
- dendrite [IDA]
- dendrite cytoplasm [IDA]
- dendritic shaft [IDA]
- dendritic spine [IDA]
- endoplasmic reticulum [ISO]
- growth cone [IDA]
- integral component of plasma membrane [IDA]
- ionotropic glutamate receptor complex [TAS]
- membrane [ISO]
- neuron projection [ISO]
- neuronal cell body [IDA]
- perikaryon [IDA]
- postsynaptic density [IDA]
- postsynaptic membrane [IBA, ISO]
- presynaptic membrane [IDA]
- protein complex [IDA, IPI]
- synapse [IDA, ISO]
- synaptic vesicle [ISO]
- synaptic vesicle membrane [IDA]
- terminal bouton [IDA]
Rattus norvegicus
PREY
SDCBP
TACIP18, mda-9
syndecan binding protein
GO Process (4)
GO Function (14)
GO Component (8)
Gene Ontology Biological Process
Gene Ontology Molecular Function- cell adhesion molecule binding [IPI]
- ephrin receptor binding [IPI]
- frizzled binding [ISO]
- glycoprotein binding [IPI]
- growth factor binding [IPI]
- identical protein binding [ISO]
- interleukin-5 receptor binding [ISO, ISS]
- neurexin family protein binding [IPI, NAS]
- protein C-terminus binding [IPI]
- protein N-terminus binding [ISO]
- protein binding [IPI]
- protein heterodimerization activity [IPI, ISO]
- protein homodimerization activity [IDA]
- syndecan binding [IPI, ISO]
- cell adhesion molecule binding [IPI]
- ephrin receptor binding [IPI]
- frizzled binding [ISO]
- glycoprotein binding [IPI]
- growth factor binding [IPI]
- identical protein binding [ISO]
- interleukin-5 receptor binding [ISO, ISS]
- neurexin family protein binding [IPI, NAS]
- protein C-terminus binding [IPI]
- protein N-terminus binding [ISO]
- protein binding [IPI]
- protein heterodimerization activity [IPI, ISO]
- protein homodimerization activity [IDA]
- syndecan binding [IPI, ISO]
Gene Ontology Cellular Component
Rattus norvegicus
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
The complexity of PDZ domain-mediated interactions at glutamatergic synapses: a case study on neuroligin.
The postsynaptic specialisation at glutamatergic synapses is composed of a network of proteins located within the membrane and the underlying postsynaptic density. The strong interconnectivity between the protein components is mediated by a limited number of interaction modes. Particularly abundant are PDZ domain-mediated interactions. An obstacle in understanding the fidelity of postsynaptic processes involving PDZ domains is the high degree ... [more]
Neuropharmacology Oct. 01, 2004; 47(5);724-33 [Pubmed: 15458844]
Throughput
- Low Throughput
Curated By
- BioGRID