BAIT
GRIK1
GluK1, GluR5
glutamate receptor, ionotropic, kainate 1
GO Process (18)
GO Function (8)
GO Component (12)
Gene Ontology Biological Process
- adult behavior [ISO]
- behavioral response to pain [ISO]
- ion transmembrane transport [IDA, ISO]
- ionotropic glutamate receptor signaling pathway [IDA, ISO]
- membrane depolarization [ISO]
- negative regulation of synaptic transmission, GABAergic [IDA]
- negative regulation of synaptic transmission, glutamatergic [IDA, ISO]
- nervous system development [IMP]
- positive regulation of gamma-aminobutyric acid secretion [ISO]
- positive regulation of synaptic transmission, GABAergic [IDA, ISO]
- regulation of excitatory postsynaptic membrane potential [ISO]
- regulation of inhibitory postsynaptic membrane potential [ISO]
- regulation of ion transmembrane transport [IMP]
- regulation of membrane potential [ISO]
- regulation of short-term neuronal synaptic plasticity [IDA]
- regulation of synaptic plasticity [TAS]
- synaptic transmission [TAS]
- synaptic transmission, glutamatergic [ISO]
Gene Ontology Molecular Function- drug binding [IDA]
- extracellular-glutamate-gated ion channel activity [IDA]
- glutamate binding [IDA]
- ionotropic glutamate receptor activity [IDA]
- kainate selective glutamate receptor activity [IDA, ISO]
- protein binding [IPI]
- protein homodimerization activity [IDA]
- voltage-gated cation channel activity [IMP]
- drug binding [IDA]
- extracellular-glutamate-gated ion channel activity [IDA]
- glutamate binding [IDA]
- ionotropic glutamate receptor activity [IDA]
- kainate selective glutamate receptor activity [IDA, ISO]
- protein binding [IPI]
- protein homodimerization activity [IDA]
- voltage-gated cation channel activity [IMP]
Gene Ontology Cellular Component
- dendrite [IDA, ISO]
- ionotropic glutamate receptor complex [IDA]
- kainate selective glutamate receptor complex [IBA, ISO]
- membrane [ISO]
- neuronal cell body [IDA]
- neuronal postsynaptic density [ISO]
- postsynaptic density [ISO]
- postsynaptic membrane [IBA]
- presynaptic membrane [IBA, ISO]
- receptor complex [IDA]
- synapse [ISO]
- terminal bouton [IDA]
Rattus norvegicus
PREY
SDCBP
TACIP18, mda-9
syndecan binding protein
GO Process (4)
GO Function (14)
GO Component (8)
Gene Ontology Biological Process
Gene Ontology Molecular Function- cell adhesion molecule binding [IPI]
- ephrin receptor binding [IPI]
- frizzled binding [ISO]
- glycoprotein binding [IPI]
- growth factor binding [IPI]
- identical protein binding [ISO]
- interleukin-5 receptor binding [ISO, ISS]
- neurexin family protein binding [IPI, NAS]
- protein C-terminus binding [IPI]
- protein N-terminus binding [ISO]
- protein binding [IPI]
- protein heterodimerization activity [IPI, ISO]
- protein homodimerization activity [IDA]
- syndecan binding [IPI, ISO]
- cell adhesion molecule binding [IPI]
- ephrin receptor binding [IPI]
- frizzled binding [ISO]
- glycoprotein binding [IPI]
- growth factor binding [IPI]
- identical protein binding [ISO]
- interleukin-5 receptor binding [ISO, ISS]
- neurexin family protein binding [IPI, NAS]
- protein C-terminus binding [IPI]
- protein N-terminus binding [ISO]
- protein binding [IPI]
- protein heterodimerization activity [IPI, ISO]
- protein homodimerization activity [IDA]
- syndecan binding [IPI, ISO]
Gene Ontology Cellular Component
Rattus norvegicus
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
The complexity of PDZ domain-mediated interactions at glutamatergic synapses: a case study on neuroligin.
The postsynaptic specialisation at glutamatergic synapses is composed of a network of proteins located within the membrane and the underlying postsynaptic density. The strong interconnectivity between the protein components is mediated by a limited number of interaction modes. Particularly abundant are PDZ domain-mediated interactions. An obstacle in understanding the fidelity of postsynaptic processes involving PDZ domains is the high degree ... [more]
Neuropharmacology Oct. 01, 2004; 47(5);724-33 [Pubmed: 15458844]
Throughput
- Low Throughput
Curated By
- BioGRID