BAIT
GRIK2
GluK2, GluR6, rCG_58533
glutamate receptor, ionotropic, kainate 2
GO Process (22)
GO Function (10)
GO Component (16)
Gene Ontology Biological Process
- behavioral fear response [ISO]
- cellular calcium ion homeostasis [ISO]
- intracellular protein transport [ISO]
- ion transmembrane transport [IBA, ISO]
- ionotropic glutamate receptor signaling pathway [IDA, ISO]
- negative regulation of neuron apoptotic process [ISO]
- negative regulation of synaptic transmission, glutamatergic [IDA, ISO]
- neuron apoptotic process [IMP]
- neuronal action potential [ISO]
- positive regulation of neuron apoptotic process [IMP]
- positive regulation of synaptic transmission [ISO]
- receptor clustering [IDA]
- regulation of JNK cascade [IMP]
- regulation of excitatory postsynaptic membrane potential [ISO]
- regulation of inhibitory postsynaptic membrane potential [ISO]
- regulation of long-term neuronal synaptic plasticity [ISO]
- regulation of membrane potential [ISO]
- regulation of short-term neuronal synaptic plasticity [ISO]
- regulation of synaptic transmission [ISO]
- signal transduction [IDA]
- synaptic transmission [IMP, ISO]
- synaptic transmission, glutamatergic [ISO]
Gene Ontology Molecular Function- PDZ domain binding [IPI]
- extracellular-glutamate-gated ion channel activity [IBA]
- glutamate receptor activity [IDA]
- identical protein binding [IDA]
- ionotropic glutamate receptor activity [ISO, TAS]
- kainate selective glutamate receptor activity [IDA, ISO]
- protein binding [IPI]
- protein homodimerization activity [IDA]
- ubiquitin conjugating enzyme binding [IPI]
- ubiquitin protein ligase binding [IPI]
- PDZ domain binding [IPI]
- extracellular-glutamate-gated ion channel activity [IBA]
- glutamate receptor activity [IDA]
- identical protein binding [IDA]
- ionotropic glutamate receptor activity [ISO, TAS]
- kainate selective glutamate receptor activity [IDA, ISO]
- protein binding [IPI]
- protein homodimerization activity [IDA]
- ubiquitin conjugating enzyme binding [IPI]
- ubiquitin protein ligase binding [IPI]
Gene Ontology Cellular Component
- axon [IDA]
- cell [ISO]
- dendrite [IDA]
- dendrite cytoplasm [IDA]
- integral component of plasma membrane [IDA]
- intracellular [ISO]
- ionotropic glutamate receptor complex [IDA]
- kainate selective glutamate receptor complex [IBA, ISO]
- membrane [ISO]
- neuronal cell body [ISO]
- perikaryon [IDA]
- postsynaptic density [ISO]
- postsynaptic membrane [IBA, ISO]
- presynaptic membrane [IBA, ISO]
- synapse [IDA, ISO]
- terminal bouton [IDA]
Rattus norvegicus
PREY
PICK1
Prkcabp
protein interacting with PRKCA 1
GO Process (17)
GO Function (15)
GO Component (12)
Gene Ontology Biological Process
- ATP catabolic process [ISO, ISS]
- cellular response to decreased oxygen levels [IMP]
- cellular response to glucose starvation [IMP]
- dendritic spine maintenance [IMP]
- dendritic spine organization [IDA]
- dopamine transport [NAS]
- glial cell development [IMP]
- long term synaptic depression [IDA]
- monoamine transport [ISO, ISS]
- negative regulation of Arp2/3 complex-mediated actin nucleation [IDA]
- negative regulation of cell death [IDA]
- negative regulation of gene expression [IMP]
- positive regulation of receptor internalization [IDA]
- protein kinase C-activating G-protein coupled receptor signaling pathway [ISO, ISS]
- protein phosphorylation [IDA]
- protein targeting [ISO]
- receptor clustering [IMP, ISO, ISS]
Gene Ontology Molecular Function- ATPase activity [ISO, ISS]
- Arp2/3 complex binding [IDA]
- G-protein coupled glutamate receptor binding [TAS]
- G-protein coupled receptor binding [IPI, TAS]
- GTPase binding [TAS]
- actin filament binding [IDA]
- enzyme binding [ISO]
- ephrin receptor binding [TAS]
- identical protein binding [IDA]
- protein C-terminus binding [IPI, ISO, ISS]
- protein binding [IPI]
- protein domain specific binding [IMP]
- protein kinase C binding [IDA, ISO, ISS]
- receptor binding [IPI, ISO, ISS]
- receptor tyrosine kinase binding [TAS]
- ATPase activity [ISO, ISS]
- Arp2/3 complex binding [IDA]
- G-protein coupled glutamate receptor binding [TAS]
- G-protein coupled receptor binding [IPI, TAS]
- GTPase binding [TAS]
- actin filament binding [IDA]
- enzyme binding [ISO]
- ephrin receptor binding [TAS]
- identical protein binding [IDA]
- protein C-terminus binding [IPI, ISO, ISS]
- protein binding [IPI]
- protein domain specific binding [IMP]
- protein kinase C binding [IDA, ISO, ISS]
- receptor binding [IPI, ISO, ISS]
- receptor tyrosine kinase binding [TAS]
Gene Ontology Cellular Component
- Golgi apparatus [ISO, ISS]
- cytoplasm [ISO, ISS]
- dendrite [IDA]
- mitochondrion [ISO]
- neuron projection [IDA]
- neuronal postsynaptic density [ISO]
- perinuclear region of cytoplasm [IDA, ISO, ISS]
- plasma membrane [ISO, ISS]
- postsynaptic density [IDA]
- presynaptic membrane [ISO, ISS]
- protein complex [IDA]
- synapse [IDA, ISO, ISS]
Rattus norvegicus
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
The complexity of PDZ domain-mediated interactions at glutamatergic synapses: a case study on neuroligin.
The postsynaptic specialisation at glutamatergic synapses is composed of a network of proteins located within the membrane and the underlying postsynaptic density. The strong interconnectivity between the protein components is mediated by a limited number of interaction modes. Particularly abundant are PDZ domain-mediated interactions. An obstacle in understanding the fidelity of postsynaptic processes involving PDZ domains is the high degree ... [more]
Neuropharmacology Oct. 01, 2004; 47(5);724-33 [Pubmed: 15458844]
Throughput
- Low Throughput
Curated By
- BioGRID