BAIT
KIT
Bs, CD117, Fdc, Gsfsco1, Gsfsco5, Gsfsow3, SCO1, SCO5, SOW3, Ssm, Tr-kit, W, c-KIT
kit oncogene
GO Process (66)
GO Function (7)
GO Component (9)
Gene Ontology Biological Process
- Fc receptor signaling pathway [ISO]
- Kit signaling pathway [IDA, ISO]
- T cell differentiation [IMP]
- actin cytoskeleton reorganization [ISO]
- activation of MAPK activity [ISO]
- cell chemotaxis [ISO]
- cell differentiation [TAS]
- cellular response to thyroid hormone stimulus [IDA]
- chemotaxis [TAS]
- cytokine-mediated signaling pathway [IDA, ISO]
- dendritic cell cytokine production [IMP]
- detection of mechanical stimulus involved in sensory perception of sound [IMP]
- developmental pigmentation [IMP]
- digestive tract development [IMP]
- ectopic germ cell programmed cell death [IGI]
- embryonic hemopoiesis [IMP]
- epithelial cell proliferation [ISO]
- erythrocyte differentiation [IMP]
- erythropoietin-mediated signaling pathway [IMP]
- germ cell development [TAS]
- germ cell migration [ISO]
- glycosphingolipid metabolic process [IMP]
- hemopoiesis [IMP]
- immature B cell differentiation [IMP]
- inflammatory response [IMP]
- intracellular signal transduction [IDA]
- lamellipodium assembly [IDA]
- lymphoid progenitor cell differentiation [IGI]
- mast cell chemotaxis [ISO]
- mast cell cytokine production [ISO]
- mast cell degranulation [ISO]
- mast cell differentiation [IMP]
- megakaryocyte development [IMP]
- melanocyte adhesion [IDA]
- melanocyte differentiation [IMP]
- melanocyte migration [IMP]
- myeloid leukocyte differentiation [IMP]
- myeloid progenitor cell differentiation [IGI]
- negative regulation of programmed cell death [IGI, IMP]
- ovarian follicle development [IMP]
- peptidyl-tyrosine phosphorylation [IDA, ISO]
- pigmentation [IGI, IMP]
- positive regulation of JAK-STAT cascade [ISO]
- positive regulation of MAP kinase activity [IGI]
- positive regulation of MAPK cascade [ISO]
- positive regulation of Notch signaling pathway [ISO]
- positive regulation of cell migration [ISO]
- positive regulation of cell proliferation [IGI, ISO]
- positive regulation of gene expression [IMP]
- positive regulation of long-term neuronal synaptic plasticity [ISO]
- positive regulation of pseudopodium assembly [ISO]
- positive regulation of sequence-specific DNA binding transcription factor activity [ISO]
- positive regulation of tyrosine phosphorylation of Stat1 protein [ISO]
- positive regulation of tyrosine phosphorylation of Stat3 protein [ISO]
- positive regulation of tyrosine phosphorylation of Stat5 protein [ISO]
- protein autophosphorylation [ISO, TAS]
- protein phosphorylation [IDA]
- regulation of cell shape [IDA]
- regulation of developmental pigmentation [IGI, IMP]
- response to radiation [IMP]
- somatic stem cell division [ISO]
- somatic stem cell maintenance [ISO]
- spermatid development [IMP]
- spermatogenesis [IMP, ISO]
- stem cell differentiation [IMP]
- visual learning [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
PREY
FES
AI586313, BB137047, FPS, c-fes
feline sarcoma oncogene
GO Process (22)
GO Function (8)
GO Component (5)
Gene Ontology Biological Process
- cell adhesion [IBA]
- cell differentiation [IBA]
- cell migration [IBA]
- centrosome organization [IMP]
- chemotaxis [IBA]
- epidermal growth factor receptor signaling pathway [IBA]
- innate immune response [IBA]
- microtubule bundle formation [IDA]
- peptidyl-tyrosine autophosphorylation [IBA]
- peptidyl-tyrosine phosphorylation [ISO]
- positive regulation of actin cytoskeleton reorganization [ISO]
- positive regulation of microtubule polymerization [ISO]
- positive regulation of myeloid cell differentiation [ISO]
- positive regulation of neuron projection development [ISO]
- protein autophosphorylation [ISO]
- protein phosphorylation [IDA]
- regulation of cell adhesion [ISO]
- regulation of cell differentiation [ISO]
- regulation of cell motility [ISO]
- regulation of cell proliferation [IBA, ISO]
- regulation of cell shape [ISO]
- regulation of mast cell degranulation [IBA, ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
Molecular cloning of murine STAP-1, the stem-cell-specific adaptor protein containing PH and SH2 domains.
To identify the novel substrate of c-kit which is important for hematopoietic stem cell self-renewal or differentiation, CD34-low/negative, Sca-1-positive, c-kit-positive, and lineage marker-negative (CD34(low/-)Sca-1(+)c-kit(+)Lin(-)) cells were sorted by a fluorescence-activated cell sorter from mouse bone marrow cells and a yeast two-hybrid cDNA library was constructed. By screening with c-kit as bait, we cloned a novel cDNA, designed STAP-1, encoding an ... [more]
Biochem. Biophys. Res. Commun. Feb. 24, 2000; 268(3);697-703 [Pubmed: 10679268]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| KIT FES | Co-fractionation Co-fractionation Interaction inferred from the presence of two or more protein subunits in a partially purified protein preparation. If co-fractionation is demonstrated between 3 or more proteins, then add them as a complex. | High | 0.912 | BioGRID | 2680395 |
Curated By
- BioGRID