BAIT
KIT
Bs, CD117, Fdc, Gsfsco1, Gsfsco5, Gsfsow3, SCO1, SCO5, SOW3, Ssm, Tr-kit, W, c-KIT
kit oncogene
GO Process (66)
GO Function (7)
GO Component (9)
Gene Ontology Biological Process
- Fc receptor signaling pathway [ISO]
- Kit signaling pathway [IDA, ISO]
- T cell differentiation [IMP]
- actin cytoskeleton reorganization [ISO]
- activation of MAPK activity [ISO]
- cell chemotaxis [ISO]
- cell differentiation [TAS]
- cellular response to thyroid hormone stimulus [IDA]
- chemotaxis [TAS]
- cytokine-mediated signaling pathway [IDA, ISO]
- dendritic cell cytokine production [IMP]
- detection of mechanical stimulus involved in sensory perception of sound [IMP]
- developmental pigmentation [IMP]
- digestive tract development [IMP]
- ectopic germ cell programmed cell death [IGI]
- embryonic hemopoiesis [IMP]
- epithelial cell proliferation [ISO]
- erythrocyte differentiation [IMP]
- erythropoietin-mediated signaling pathway [IMP]
- germ cell development [TAS]
- germ cell migration [ISO]
- glycosphingolipid metabolic process [IMP]
- hemopoiesis [IMP]
- immature B cell differentiation [IMP]
- inflammatory response [IMP]
- intracellular signal transduction [IDA]
- lamellipodium assembly [IDA]
- lymphoid progenitor cell differentiation [IGI]
- mast cell chemotaxis [ISO]
- mast cell cytokine production [ISO]
- mast cell degranulation [ISO]
- mast cell differentiation [IMP]
- megakaryocyte development [IMP]
- melanocyte adhesion [IDA]
- melanocyte differentiation [IMP]
- melanocyte migration [IMP]
- myeloid leukocyte differentiation [IMP]
- myeloid progenitor cell differentiation [IGI]
- negative regulation of programmed cell death [IGI, IMP]
- ovarian follicle development [IMP]
- peptidyl-tyrosine phosphorylation [IDA, ISO]
- pigmentation [IGI, IMP]
- positive regulation of JAK-STAT cascade [ISO]
- positive regulation of MAP kinase activity [IGI]
- positive regulation of MAPK cascade [ISO]
- positive regulation of Notch signaling pathway [ISO]
- positive regulation of cell migration [ISO]
- positive regulation of cell proliferation [IGI, ISO]
- positive regulation of gene expression [IMP]
- positive regulation of long-term neuronal synaptic plasticity [ISO]
- positive regulation of pseudopodium assembly [ISO]
- positive regulation of sequence-specific DNA binding transcription factor activity [ISO]
- positive regulation of tyrosine phosphorylation of Stat1 protein [ISO]
- positive regulation of tyrosine phosphorylation of Stat3 protein [ISO]
- positive regulation of tyrosine phosphorylation of Stat5 protein [ISO]
- protein autophosphorylation [ISO, TAS]
- protein phosphorylation [IDA]
- regulation of cell shape [IDA]
- regulation of developmental pigmentation [IGI, IMP]
- response to radiation [IMP]
- somatic stem cell division [ISO]
- somatic stem cell maintenance [ISO]
- spermatid development [IMP]
- spermatogenesis [IMP, ISO]
- stem cell differentiation [IMP]
- visual learning [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
PREY
PLK1
Plk, STPK13
polo-like kinase 1
GO Process (27)
GO Function (6)
GO Component (12)
Gene Ontology Biological Process
- G2 DNA damage checkpoint [ISO]
- G2/M transition of mitotic cell cycle [ISO]
- activation of mitotic anaphase-promoting complex activity [ISO]
- centrosome organization [ISO]
- cytokinesis [ISO]
- establishment of protein localization [ISO]
- microtubule bundle formation [ISO]
- mitotic cytokinesis [ISO]
- mitotic nuclear division [ISO]
- mitotic sister chromatid segregation [ISO]
- mitotic spindle assembly checkpoint [ISO]
- negative regulation of apoptotic process [ISO]
- negative regulation of cyclin-dependent protein serine/threonine kinase activity [ISO]
- negative regulation of transcription from RNA polymerase II promoter [ISO]
- peptidyl-serine phosphorylation [ISO]
- polar body extrusion after meiotic divisions [ISO]
- positive regulation of peptidyl-threonine phosphorylation [ISO]
- positive regulation of proteasomal ubiquitin-dependent protein catabolic process [ISO]
- positive regulation of proteolysis [ISO]
- positive regulation of ubiquitin-protein transferase activity [ISO]
- protein destabilization [ISO]
- protein localization to chromatin [ISO]
- protein phosphorylation [IDA, ISO]
- protein ubiquitination [ISO]
- regulation of mitotic cell cycle [ISO]
- regulation of mitotic metaphase/anaphase transition [ISO]
- regulation of protein binding [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
Molecular cloning of murine STAP-1, the stem-cell-specific adaptor protein containing PH and SH2 domains.
To identify the novel substrate of c-kit which is important for hematopoietic stem cell self-renewal or differentiation, CD34-low/negative, Sca-1-positive, c-kit-positive, and lineage marker-negative (CD34(low/-)Sca-1(+)c-kit(+)Lin(-)) cells were sorted by a fluorescence-activated cell sorter from mouse bone marrow cells and a yeast two-hybrid cDNA library was constructed. By screening with c-kit as bait, we cloned a novel cDNA, designed STAP-1, encoding an ... [more]
Biochem. Biophys. Res. Commun. Feb. 24, 2000; 268(3);697-703 [Pubmed: 10679268]
Throughput
- Low Throughput
Curated By
- BioGRID