BAIT

PMC1

SPBP23A10.01c, med14, SPBC1A4.10c
mediator complex subunit Pmc1
GO Process (0)
GO Function (0)
GO Component (3)

Gene Ontology Cellular Component

Schizosaccharomyces pombe (972h)
PREY

RYH1

hos1, sat7, SPAC4C5.02c
GTPase Ryh1
GO Process (2)
GO Function (2)
GO Component (3)

Gene Ontology Biological Process

Gene Ontology Molecular Function

Gene Ontology Cellular Component

Schizosaccharomyces pombe (972h)

Synthetic Growth Defect

A genetic interaction is inferred when mutations in separate genes, each of which alone causes a minimal phenotype, result in a significant growth defect under a given condition when combined in the same cell.

Publication

Fission yeast TOR signaling is essential for the down-regulation of a hyperactivated stress-response MAP kinase under salt stress.

Ishiguro J, Shibahara K, Ueda Y, Nakamura K

TOR (target of rapamycin) signaling regulates cell growth and division in response to environmental stimuli such as the availability of nutrients and various forms of stress. The vegetative growth of fission yeast cells, unlike other eukaryotic cells, is not inhibited by treatment with rapamycin. We found that certain mutations including pmc1Δ (Ca(2+)-ATPase), cps9-193 (small GTPase, Ryh1) and cps1-12 (1,3-β-D-glucan synthase, ... [more]

Mol. Genet. Genomics Dec. 28, 2012; 0(0); [Pubmed: 23271606]

Throughput

  • Low Throughput

Ontology Terms

  • resistance to chemicals (APO:0000087)
  • vegetative growth (APO:0000106)

Additional Notes

  • double mutants show increased sensitivity to rapamycin (CHEBI 9168 CID 5284616)

Curated By

  • BioGRID