Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.

Publication

Protein Phosphatase 1Î³ Isoforms Linked Interactions in the Brain.

Esteves SL, Korrodi-Gregorio L, Cotrim CZ, van Kleeff PJ, Domingues SC, da Cruz E Silva OA, Fardilha M, da Cruz E Silva EF

Posttranslational protein modifications, in particular reversible protein phosphorylation, are important regulatory mechanisms involved in cellular signaling transduction pathways. Thousands of human proteins are phosphorylatable and the tight regulation of phosphorylation states is crucial for cell maintenance and development. Protein phosphorylation occurs primarily on serine, threonine, and tyrosine residues, through the antagonistic actions of protein kinases and phosphatases. The catalytic subunit ... [more]

J. Mol. Neurosci. Oct. 19, 2012; 0(0); [Pubmed: 23080069]

Throughput

High Throughput

Related interactions

Interaction	Experimental Evidence Code	Dataset	Throughput	Score	Curated By	Notes
PPP1CC C1QA	Two-hybrid Two-hybrid Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.	Fardilha M (2011)	Low	-	BioGRID	-

Curated By

BioGRID

Interaction Summary

PPP1CC

Gene Ontology Biological Process

Gene Ontology Molecular Function

phosphatase activity [ISS]phosphoprotein phosphatase activity [TAS]poly(A) RNA binding [IDA]protein binding [IPI]protein kinase binding [IPI]protein serine/threonine phosphatase activity [IMP]

Gene Ontology Cellular Component

C1QA