MPS3
Gene Ontology Biological Process
- chromatin silencing at telomere [IMP]
- establishment of mitotic sister chromatid cohesion [IMP]
- karyogamy [IMP]
- meiotic telomere clustering [IGI, IMP]
- mitotic sister chromatid cohesion [IMP]
- nuclear migration involved in conjugation with cellular fusion [IMP]
- spindle pole body duplication [IMP]
- synapsis [IGI, IMP]
- telomere tethering at nuclear periphery [IMP]
Gene Ontology Cellular Component
ARF1
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Synthetic Lethality
A genetic interaction is inferred when mutations or deletions in separate genes, each of which alone causes a minimal phenotype, result in lethality when combined in the same cell under a given condition.
Publication
Genetic Analysis of Mps3 SUN Domain Mutants in Saccharomyces cerevisiae Reveals an Interaction with the SUN-Like Protein Slp1.
In virtually all eukaryotic cells, protein bridges formed by the conserved inner nuclear membrane SUN (for Sad1-UNC-84) domain-containing proteins and their outer nuclear membrane binding partners span the nuclear envelope (NE) to connect the nucleoplasm and cytoplasm. These linkages are important for chromosome movements within the nucleus during meiotic prophase and are essential for nuclear migration and centrosome attachment to ... [more]
Throughput
- High Throughput|Low Throughput
Ontology Terms
- phenotype: inviable (APO:0000112)
Additional Notes
- High Throughput: SGA screen
- Low Throughput: verification of hit by random sporulation and/or tetrad dissection
- mps3-F592S allele
Related interactions
Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
---|---|---|---|---|---|---|
MPS3 ARF1 | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | High | - | BioGRID | 2543295 |
Curated By
- BioGRID