SIRT3
Gene Ontology Biological Process
- aerobic respiration [ISO]
- histone H3 deacetylation [IDA]
- negative regulation of ERK1 and ERK2 cascade [ISO]
- negative regulation of peptidyl-lysine acetylation [IDA, IMP]
- negative regulation of reactive oxygen species metabolic process [ISO]
- peptidyl-lysine deacetylation [ISO]
- positive regulation of insulin secretion [ISO]
- protein deacetylation [IDA, ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
NDUFA9
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Biochemical Activity (Deacetylation)
An interaction is inferred from the biochemical effect of one protein upon another, for example, GTP-GDP exchange activity or phosphorylation of a substrate by a kinase. The bait protein executes the activity on the substrate hit protein. A Modification value is recorded for interactions of this type with the possible values Phosphorylation, Ubiquitination, Sumoylation, Dephosphorylation, Methylation, Prenylation, Acetylation, Deubiquitination, Proteolytic Processing, Glucosylation, Nedd(Rub1)ylation, Deacetylation, No Modification, Demethylation.
Publication
A role for the mitochondrial deacetylase Sirt3 in regulating energy homeostasis.
Here, we demonstrate a role for the mitochondrial NAD-dependent deacetylase Sirt3 in the maintenance of basal ATP levels and as a regulator of mitochondrial electron transport. We note that Sirt3(-/-) mouse embryonic fibroblasts have a reduction in basal ATP levels. Reconstitution with wild-type but not a deacetylase-deficient form of Sirt3 restored ATP levels in these cells. Furthermore in wild-type mice, ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID