SIRT3
Gene Ontology Biological Process
- aerobic respiration [ISO]
- histone H3 deacetylation [IDA]
- negative regulation of ERK1 and ERK2 cascade [ISO]
- negative regulation of peptidyl-lysine acetylation [IDA, IMP]
- negative regulation of reactive oxygen species metabolic process [ISO]
- peptidyl-lysine deacetylation [ISO]
- positive regulation of insulin secretion [ISO]
- protein deacetylation [IDA, ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
NDUFA9
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
A role for the mitochondrial deacetylase Sirt3 in regulating energy homeostasis.
Here, we demonstrate a role for the mitochondrial NAD-dependent deacetylase Sirt3 in the maintenance of basal ATP levels and as a regulator of mitochondrial electron transport. We note that Sirt3(-/-) mouse embryonic fibroblasts have a reduction in basal ATP levels. Reconstitution with wild-type but not a deacetylase-deficient form of Sirt3 restored ATP levels in these cells. Furthermore in wild-type mice, ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID