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BAIT

FBXW7

AGO, CDC4, FBW6, FBW7, FBX30, FBXO30, FBXW6, SEL-10, SEL10, hAgo, hCdc4

F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase

GO Process (24)

GO Function (6)

GO Component (6)

Gene Ontology Biological Process

Notch signaling pathway [TAS]

SCF-dependent proteasomal ubiquitin-dependent protein catabolic process [IDA]

cellular response to DNA damage stimulus [IDA]

cellular response to UV [IDA]

lipid homeostasis [ISS]

negative regulation of DNA endoreduplication [IMP]

negative regulation of Notch signaling pathway [ISS]

negative regulation of SREBP signaling pathway [ISS]

negative regulation of hepatocyte proliferation [ISS]

negative regulation of triglyceride biosynthetic process [ISS]

positive regulation of ERK1 and ERK2 cascade [IMP]

positive regulation of epidermal growth factor-activated receptor activity [IDA]

positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway [IDA]

positive regulation of proteasomal protein catabolic process [IDA]

positive regulation of protein ubiquitination [IDA]

positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process [IDA]

positive regulation of ubiquitin-protein transferase activity [IDA]

protein stabilization [IDA]

protein ubiquitination [IDA]

regulation of cell cycle G1/S phase transition [TAS]

regulation of lipid storage [ISS]

regulation of protein localization [ISS]

sister chromatid cohesion [IMP]

vasculature development [TAS]

Gene Ontology Molecular Function

cyclin binding [IDA]
identical protein binding [IPI]
protein binding [IPI]
protein binding, bridging [IDA]
ubiquitin protein ligase binding [IPI]
ubiquitin-protein transferase activator activity [IDA]

Gene Ontology Cellular Component

Parkin-FBXW7-Cul1 ubiquitin ligase complex [IPI]

SCF ubiquitin ligase complex [IDA]

cytoplasm [IDA]

nucleolus [IDA]

nucleoplasm [IDA, TAS]

protein complex [IDA]

CRISPR Database HGNC Alliance of Genome Resources OMIM VEGA Entrez Gene RefSeq UniprotKB Ensembl HPRD

Homo sapiens

PREY

MED22

MED24, SURF5, surf-5, RP11-244N20.9

mediator complex subunit 22

GO Process (0)

GO Function (1)

GO Component (2)

Gene Ontology Molecular Function

protein binding [IPI]

Gene Ontology Cellular Component

cytoplasm [TAS]

mediator complex [IDA]

CRISPR Database VEGA HGNC Alliance of Genome Resources OMIM Entrez Gene RefSeq UniprotKB Ensembl HPRD

Homo sapiens

Affinity Capture-MS

An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.

Publication

The SCF-Fbw7 ubiquitin ligase degrades MED13 and MED13L and regulates CDK8 module association with Mediator.

Davis MA, Larimore EA, Fissel BM, Swanger J, Taatjes DJ, Clurman BE

The Mediator complex is an essential transcription regulator that bridges transcription factors with RNA polymerase II. This interaction is controlled by dynamic interactions between Mediator and the CDK8 module, but the mechanisms governing CDK8 module-Mediator association remain poorly understood. We show that Fbw7, a tumor suppressor and ubiquitin ligase, binds to CDK8-Mediator and targets MED13/13L for degradation. MED13/13L physically link ... [more]

Genes Dev. Jan. 15, 2013; 27(2);151-6 [Pubmed: 23322298]

Throughput

Low Throughput

Related interactions

Interaction	Experimental Evidence Code	Dataset	Throughput	Score	Curated By	Notes
FBXW7 MED22	Synthetic Lethality Synthetic Lethality A genetic interaction is inferred when mutations or deletions in separate genes, each of which alone causes a minimal phenotype, result in lethality when combined in the same cell under a given condition.	Bailey ML (2015)	Low	-	BioGRID	1518060

Curated By

BioGRID