PPA2
Gene Ontology Biological Process
Gene Ontology Molecular Function
ZFS1
Gene Ontology Biological Process
Gene Ontology Molecular Function
Phenotypic Enhancement
A genetic interaction is inferred when mutation or overexpression of one gene results in enhancement of any phenotype (other than lethality/growth defect) associated with mutation or over expression of another gene.
Publication
A systematic screen reveals new elements acting at the G2/M cell cycle control.
ABSTRACT: BACKGROUND: The major cell cycle control acting at the G2 to mitosis transition is triggered in all eukaryotes by cyclin-dependent kinases (CDKs). In the fission yeast Schizosaccharomyces pombe the activation of the G2/M CDK is regulated primarily by dephosphorylation of the conserved residue Tyr15 in response to the stress-nutritional response and cell geometry sensing pathways. To obtain a more ... [more]
Throughput
- Low Throughput
Ontology Terms
- phenotype: cell size (APO:0000052)
Additional Notes
- double mutants show decreased cell length at division compared to single mutants
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| PPA2 ZFS1 | Negative Genetic Negative Genetic Mutations/deletions in separate genes, each of which alone causes a minimal phenotype, but when combined in the same cell results in a more severe fitness defect or lethality under a given condition. This term is reserved for high or low throughput studies with scores. | High | -6.0187 | BioGRID | 768475 |
Curated By
- BioGRID