BAIT
RAB21
RAB21, member RAS oncogene family
GO Process (7)
GO Function (4)
GO Component (9)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
APPL1
APPL, DIP13alpha
adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 1
GO Process (8)
GO Function (3)
GO Component (7)
Gene Ontology Biological Process
- apoptotic process [TAS]
- cell proliferation [IDA]
- insulin receptor signaling pathway [TAS]
- positive regulation of apoptotic process [TAS]
- regulation of apoptotic process [TAS]
- regulation of establishment of protein localization to plasma membrane [IMP]
- regulation of glucose import [IMP]
- signal transduction [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Reconstituted Complex
An interaction is detected between purified proteins in vitro.
Publication
Structure of the APPL1 BAR-PH domain and characterization of its interaction with Rab5.
APPL1 is an effector of the small GTPase Rab5. Together, they mediate a signal transduction pathway initiated by ligand binding to cell surface receptors. Interaction with Rab5 is confined to the amino (N)-terminal region of APPL1. We report the crystal structures of human APPL1 N-terminal BAR-PH domain motif. The BAR and PH domains, together with a novel linker helix, form ... [more]
EMBO J. Jul. 25, 2007; 26(14);3484-93 [Pubmed: 17581628]
Throughput
- Low Throughput
Curated By
- BioGRID