BAIT
RBPJ
AI843960, CBF1, Igkjrb, Igkrsbp, RBP-J, RBP-J kappa, RBPjk, Rbpsuh
recombination signal binding protein for immunoglobulin kappa J region
GO Process (66)
GO Function (11)
GO Component (8)
Gene Ontology Biological Process
- B cell differentiation [IMP]
- Clara cell differentiation [IMP]
- Notch signaling pathway [IMP, ISO]
- Notch signaling pathway involved in arterial endothelial cell fate commitment [IC]
- angiogenesis [IMP]
- arterial endothelial cell fate commitment [IMP]
- atrioventricular canal development [IMP]
- auditory receptor cell fate commitment [IMP]
- blood vessel endothelial cell fate specification [IGI]
- blood vessel lumenization [IMP]
- blood vessel remodeling [IMP]
- cardiac left ventricle morphogenesis [IMP]
- cell fate commitment [IMP]
- defense response to bacterium [IMP]
- determination of heart left/right asymmetry [TAS]
- dorsal aorta morphogenesis [IMP]
- endocardium development [IMP]
- endocardium morphogenesis [IMP]
- epidermal cell fate specification [IMP]
- epithelial to mesenchymal transition [IMP]
- epithelial to mesenchymal transition involved in endocardial cushion formation [IMP]
- hair follicle maturation [IMP]
- heart development [IMP]
- heart looping [TAS]
- hemopoiesis [IMP]
- humoral immune response [IMP]
- inflammatory response to antigenic stimulus [IMP]
- interleukin-4 secretion [IMP]
- keratinocyte differentiation [IMP]
- labyrinthine layer blood vessel development [IMP]
- myeloid dendritic cell differentiation [IMP]
- negative regulation of cell differentiation [IMP]
- negative regulation of cell proliferation [IMP]
- negative regulation of neuron projection development [ISO]
- negative regulation of ossification [IMP]
- negative regulation of smooth muscle cell apoptotic process [ISO]
- negative regulation of smooth muscle cell migration [ISO]
- negative regulation of transcription from RNA polymerase II promoter [IMP, ISO]
- negative regulation of transcription, DNA-templated [IDA, ISO]
- neuron differentiation [IMP]
- outflow tract morphogenesis [IMP]
- pituitary gland development [IMP]
- positive regulation of BMP signaling pathway [IMP]
- positive regulation of ERBB signaling pathway [IMP]
- positive regulation of Notch signaling pathway involved in heart induction [TAS]
- positive regulation of canonical Wnt signaling pathway involved in cardiac muscle cell fate commitment [IMP]
- positive regulation of cardiac muscle cell proliferation [IMP]
- positive regulation of cell proliferation [IGI]
- positive regulation of cell proliferation involved in heart morphogenesis [IMP]
- positive regulation of ephrin receptor signaling pathway [IMP]
- positive regulation of gene expression [IMP]
- positive regulation of smooth muscle cell proliferation [ISO]
- positive regulation of transcription from RNA polymerase II promoter [IDA, IMP, ISO]
- positive regulation of transcription of Notch receptor target [IGI, ISO]
- positive regulation of transcription, DNA-templated [ISA, ISO]
- regulation of cell adhesion involved in heart morphogenesis [IC]
- regulation of gene expression [IMP]
- regulation of timing of cell differentiation [IMP]
- regulation of transcription from RNA polymerase II promoter [IGI]
- regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation [IMP]
- sebaceous gland development [IMP]
- secondary heart field specification [IGI, IMP]
- somatic stem cell maintenance [IMP]
- somitogenesis [IMP, TAS]
- transcription from RNA polymerase II promoter [IDA]
- ventricular trabecula myocardium morphogenesis [IMP]
Gene Ontology Molecular Function- DNA binding [IDA, ISA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [ISO]
- RNA polymerase II core promoter sequence-specific DNA binding [IDA]
- RNA polymerase II repressing transcription factor binding [ISO]
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [IDA]
- chromatin binding [IDA]
- protein N-terminus binding [IPI]
- protein binding [IPI]
- protein complex binding [ISO]
- sequence-specific DNA binding [IDA]
- transcription factor binding [IPI]
- DNA binding [IDA, ISA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [ISO]
- RNA polymerase II core promoter sequence-specific DNA binding [IDA]
- RNA polymerase II repressing transcription factor binding [ISO]
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [IDA]
- chromatin binding [IDA]
- protein N-terminus binding [IPI]
- protein binding [IPI]
- protein complex binding [ISO]
- sequence-specific DNA binding [IDA]
- transcription factor binding [IPI]
Gene Ontology Cellular Component
Mus musculus
PREY
NOTCH4
Int-3, Int3, N4, RP23-24A13.10-001
notch 4
GO Process (8)
GO Function (1)
GO Component (1)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Murine notch homologs (N1-4) undergo presenilin-dependent proteolysis.
Oncogenic forms of Notch1, Notch2, and Notch4 appear to mimic signaling intermediates of Notch1 and suggest that the role of proteolysis in Notch signaling has been conserved. Here we demonstrate that extracellularly truncated Notch homologs are substrates for a presenilin-dependent gamma-secretase activity. Despite minimal conservation within the transmembrane domain, the requirement for a specific amino acid (P1' valine) and its ... [more]
J. Biol. Chem. Oct. 26, 2001; 276(43);40268-73 [Pubmed: 11518718]
Throughput
- Low Throughput
Curated By
- BioGRID