BAIT
CAMK2D
CAMK1, Camk2, Camki, RATCAMKI
calcium/calmodulin-dependent protein kinase II delta
GO Process (33)
GO Function (9)
GO Component (13)
Gene Ontology Biological Process
- G1/S transition of mitotic cell cycle [ISO]
- calcium ion transport [ISO]
- cardiac muscle cell contraction [IDA]
- cardiac muscle contraction [ISO]
- cell growth involved in cardiac muscle cell development [IMP]
- cellular potassium ion homeostasis [IMP]
- endoplasmic reticulum calcium ion homeostasis [IDA]
- negative regulation of sodium ion transmembrane transport [ISO]
- negative regulation of sodium ion transmembrane transporter activity [ISO]
- peptidyl-serine phosphorylation [IDA, ISO]
- peptidyl-threonine phosphorylation [IDA, ISO]
- positive regulation of ERK1 and ERK2 cascade [IMP]
- positive regulation of Rac protein signal transduction [IMP]
- positive regulation of cardiac muscle hypertrophy [ISO, ISS]
- positive regulation of smooth muscle cell migration [IMP]
- positive regulation of smooth muscle cell proliferation [IMP]
- protein autophosphorylation [IDA, ISO]
- protein oligomerization [ISO]
- protein phosphorylation [IDA, ISO, ISS]
- regulation of G2/M transition of mitotic cell cycle [IMP]
- regulation of cardiac muscle cell action potential [IDA]
- regulation of cardiac muscle cell action potential involved in regulation of contraction [IC]
- regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion [IC]
- regulation of cell communication by electrical coupling [IDA]
- regulation of cell communication by electrical coupling involved in cardiac conduction [IC]
- regulation of cellular localization [ISO, ISS]
- regulation of generation of L-type calcium current [IDA]
- regulation of membrane depolarization [ISO]
- regulation of relaxation of cardiac muscle [IDA, ISO]
- regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum [IDA]
- regulation of sodium ion transport [ISO]
- relaxation of cardiac muscle [IDA]
- response to hypoxia [IMP]
Gene Ontology Molecular Function- calmodulin binding [ISO]
- calmodulin-dependent protein kinase activity [IDA, IMP, ISO]
- ion channel binding [IDA, IPI, ISO]
- nitric-oxide synthase binding [IPI]
- protein binding [IPI]
- protein homodimerization activity [ISO]
- protein serine/threonine kinase activity [ISO]
- sodium channel inhibitor activity [ISO]
- titin binding [ISO]
- calmodulin binding [ISO]
- calmodulin-dependent protein kinase activity [IDA, IMP, ISO]
- ion channel binding [IDA, IPI, ISO]
- nitric-oxide synthase binding [IPI]
- protein binding [IPI]
- protein homodimerization activity [ISO]
- protein serine/threonine kinase activity [ISO]
- sodium channel inhibitor activity [ISO]
- titin binding [ISO]
Gene Ontology Cellular Component
- T-tubule [ISO]
- axon initial segment [ISO]
- calcium channel complex [IDA, ISO]
- cytoplasm [IDA, ISO]
- cytosol [IDA]
- intercalated disc [ISO]
- membrane [ISO]
- neuromuscular junction [ISO]
- neuronal cell body [ISO]
- nucleus [IDA, ISO]
- perinuclear region of cytoplasm [IDA]
- protein complex [IDA]
- sarcoplasmic reticulum [ISO]
Rattus norvegicus
PREY
GRIN2A
GluN2A, NMDAR2A, NR2A
glutamate receptor, ionotropic, N-methyl D-aspartate 2A
GO Process (62)
GO Function (19)
GO Component (13)
Gene Ontology Biological Process
- action potential [IMP]
- calcium ion transmembrane transport [ISO]
- calcium ion transport [ISO]
- cation transmembrane transport [IDA]
- cation transport [IDA]
- cellular response to amino acid stimulus [IMP]
- cellular response to dsRNA [IEP]
- cellular response to growth factor stimulus [IEP]
- cellular response to lipid [IEP]
- cellular response to magnesium ion [IEP]
- cellular response to manganese ion [IEP]
- cellular response to zinc ion [IMP]
- cerebral cortex development [IEP]
- detection of mechanical stimulus involved in sensory perception of pain [ISO]
- directional locomotion [ISO]
- dopamine metabolic process [ISO]
- hippocampus development [IEP]
- ion transmembrane transport [IMP, ISO]
- ionotropic glutamate receptor signaling pathway [IDA, ISO]
- learning [ISO]
- learning or memory [ISO]
- locomotion [ISO]
- memory [IDA, ISO]
- negative regulation of protein catabolic process [ISO]
- neurogenesis [ISO]
- positive regulation of apoptotic process [ISO]
- positive regulation of cell death [IDA]
- positive regulation of excitatory postsynaptic membrane potential [IDA]
- protein localization [ISO]
- protein tetramerization [IDA]
- regulation of excitatory postsynaptic membrane potential [IMP, ISO]
- regulation of ion transmembrane transport [IMP]
- regulation of long-term neuronal synaptic plasticity [IMP]
- regulation of membrane potential [ISO]
- regulation of postsynaptic membrane potential [ISO]
- regulation of sensory perception of pain [ISO]
- regulation of synaptic plasticity [ISO]
- regulation of synaptic transmission [ISO]
- response to amine [IEP]
- response to ammonium ion [IEP]
- response to amphetamine [ISO]
- response to calcium ion [IEP]
- response to carbohydrate [IEP]
- response to cocaine [IEP]
- response to drug [IEP, ISO]
- response to ethanol [IEP, ISO]
- response to fungicide [IEP]
- response to light stimulus [IEP]
- response to manganese ion [IEP]
- response to methylmercury [IEP]
- response to organic cyclic compound [IEP]
- response to other organism [IEP]
- response to wounding [ISO]
- rhythmic process [IDA]
- sensory perception of pain [ISO]
- serotonin metabolic process [ISO]
- sleep [ISO]
- spinal cord development [IEP]
- startle response [ISO]
- synaptic transmission [IMP, ISO]
- synaptic transmission, glutamatergic [IBA]
- visual learning [ISO]
Gene Ontology Molecular Function- ATPase binding [IPI]
- N-methyl-D-aspartate selective glutamate receptor activity [IDA, IMP, ISO]
- calcium channel activity [ISO]
- cation channel activity [IDA, ISO]
- cell adhesion molecule binding [IPI]
- extracellular-glutamate-gated ion channel activity [IMP]
- glutamate binding [IDA, IMP]
- glutamate receptor binding [IPI]
- ionotropic glutamate receptor activity [IDA, IMP]
- neurotransmitter binding [IDA]
- protein binding [IPI]
- protein complex binding [IPI]
- protein dimerization activity [IDA]
- protein heterodimerization activity [IDA]
- protein kinase binding [IPI]
- receptor binding [IPI]
- scaffold protein binding [IPI]
- voltage-gated cation channel activity [IMP]
- zinc ion binding [IDA, ISS]
- ATPase binding [IPI]
- N-methyl-D-aspartate selective glutamate receptor activity [IDA, IMP, ISO]
- calcium channel activity [ISO]
- cation channel activity [IDA, ISO]
- cell adhesion molecule binding [IPI]
- extracellular-glutamate-gated ion channel activity [IMP]
- glutamate binding [IDA, IMP]
- glutamate receptor binding [IPI]
- ionotropic glutamate receptor activity [IDA, IMP]
- neurotransmitter binding [IDA]
- protein binding [IPI]
- protein complex binding [IPI]
- protein dimerization activity [IDA]
- protein heterodimerization activity [IDA]
- protein kinase binding [IPI]
- receptor binding [IPI]
- scaffold protein binding [IPI]
- voltage-gated cation channel activity [IMP]
- zinc ion binding [IDA, ISS]
Gene Ontology Cellular Component
- N-methyl-D-aspartate selective glutamate receptor complex [IDA, ISO]
- cell surface [ISO]
- dendritic spine [IDA]
- endoplasmic reticulum [ISO]
- membrane [ISO]
- neuron projection [IDA, ISO]
- neuronal postsynaptic density [ISO]
- postsynaptic density [IDA, ISO]
- postsynaptic membrane [IBA, ISO]
- presynaptic membrane [IDA, ISO]
- synapse [ISO, TAS]
- synaptic vesicle [ISO]
- terminal bouton [IDA]
Rattus norvegicus
Biochemical Activity (Phosphorylation)
An interaction is inferred from the biochemical effect of one protein upon another, for example, GTP-GDP exchange activity or phosphorylation of a substrate by a kinase. The bait protein executes the activity on the substrate hit protein. A Modification value is recorded for interactions of this type with the possible values Phosphorylation, Ubiquitination, Sumoylation, Dephosphorylation, Methylation, Prenylation, Acetylation, Deubiquitination, Proteolytic Processing, Glucosylation, Nedd(Rub1)ylation, Deacetylation, No Modification, Demethylation.
Publication
Sequence determinants on the NR2A and NR2B subunits of NMDA receptor responsible for specificity of phosphorylation by CaMKII.
Calcium/calmodulin-dependent protein kinase type II (CaMKII) and NMDA-type glutamate receptor (NMDAR) are neuronal proteins involved in learning and memory. CaMKII binds to the NR2B subunit of NMDAR in more than one mode, a stable association involving a noncatalytic site on CaMKII and an enzyme-substrate mode of interaction by its catalytic site. The latter binding results in phosphorylation of serine-1303 on ... [more]
Biochim. Biophys. Acta Jul. 29, 2002; 1598(1);40-5 [Pubmed: 12147342]
Throughput
- Low Throughput
Curated By
- BioGRID