IRS2
Gene Ontology Biological Process
- brain development [ISO]
- cell proliferation [ISO]
- cellular response to glucose stimulus [IEP]
- cellular response to insulin stimulus [IDA, ISO]
- cellular response to peptide [IEP]
- insulin receptor signaling pathway [IMP, ISO]
- mammary gland development [ISO]
- negative regulation of B cell apoptotic process [ISO]
- negative regulation of kinase activity [ISO]
- negative regulation of plasma membrane long-chain fatty acid transport [ISO]
- positive regulation of B cell proliferation [ISO]
- positive regulation of cell migration [ISO]
- positive regulation of cell proliferation [ISO]
- positive regulation of fatty acid beta-oxidation [ISO]
- positive regulation of glucose import [ISO]
- positive regulation of glucose metabolic process [ISO]
- positive regulation of glycogen biosynthetic process [ISO]
- positive regulation of insulin secretion [ISO]
- positive regulation of mesenchymal cell proliferation [ISO]
- regulation of lipid metabolic process [IBA]
- response to glucose [ISO]
Gene Ontology Molecular Function
GRB2
Gene Ontology Biological Process
- Ras protein signal transduction [TAS]
- aging [IPI]
- anatomical structure formation involved in morphogenesis [ISO]
- branching involved in labyrinthine layer morphogenesis [ISO]
- cell differentiation [ISO]
- cellular response to ionizing radiation [ISO]
- fibroblast growth factor receptor signaling pathway [ISO]
- insulin receptor signaling pathway [ISO]
- positive regulation of actin filament polymerization [ISO]
- positive regulation of reactive oxygen species metabolic process [ISO]
- positive regulation of signal transduction [ISO]
- protein heterooligomerization [IDA]
- receptor internalization [ISO]
- regulation of MAPK cascade [ISO]
- signal transduction in response to DNA damage [ISO]
Gene Ontology Molecular Function- SH3 domain binding [ISO, ISS]
- SH3/SH2 adaptor activity [ISO]
- ephrin receptor binding [ISO]
- epidermal growth factor receptor binding [IPI, ISO, ISS]
- identical protein binding [ISO]
- insulin receptor substrate binding [IPI, ISO]
- neurotrophin TRKA receptor binding [ISO]
- phosphoprotein binding [IPI]
- phosphotyrosine binding [IPI]
- poly(A) RNA binding [ISO]
- protein binding [IPI]
- protein domain specific binding [IPI, ISO]
- protein kinase binding [ISO]
- protein phosphatase binding [ISO]
- SH3 domain binding [ISO, ISS]
- SH3/SH2 adaptor activity [ISO]
- ephrin receptor binding [ISO]
- epidermal growth factor receptor binding [IPI, ISO, ISS]
- identical protein binding [ISO]
- insulin receptor substrate binding [IPI, ISO]
- neurotrophin TRKA receptor binding [ISO]
- phosphoprotein binding [IPI]
- phosphotyrosine binding [IPI]
- poly(A) RNA binding [ISO]
- protein binding [IPI]
- protein domain specific binding [IPI, ISO]
- protein kinase binding [ISO]
- protein phosphatase binding [ISO]
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
The cross-talk between angiotensin and insulin differentially affects phosphatidylinositol 3-kinase- and mitogen-activated protein kinase-mediated signaling in rat heart: implications for insulin resistance.
Insulin and angiotensin II (AngII) may act through overlapping intracellular pathways to promote cardiac myocyte growth. In this report insulin and AngII signaling, through the phosphatidylinositol 3-kinase (PI 3-kinase) and MAPK pathways, were compared in cardiac tissues of control and obese Zucker rats. AngII induced Janus kinase 2 tyrosine phosphorylation and coimmunoprecipitation with insulin receptor substrate 1 (IRS-1) and IRS-2 ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| GRB2 IRS2 | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - |
Curated By
- BioGRID