TUBB3
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
DPYSL2
Gene Ontology Biological Process
- brain development [IEP]
- cytoskeleton organization [ISO, ISS]
- endocytosis [ISO, ISS]
- olfactory bulb development [IEP]
- positive regulation of glutamate secretion [IDA]
- regulation of axon extension [NAS]
- regulation of neuron differentiation [IMP]
- regulation of neuron projection development [ISO]
- response to amphetamine [IEP]
- response to cocaine [IEP]
- response to drug [IEP]
- spinal cord development [IEP]
- synaptic vesicle transport [IDA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
CRMP-2 binds to tubulin heterodimers to promote microtubule assembly.
Regulated increase in the formation of microtubule arrays is thought to be important for axonal growth. Collapsin response mediator protein-2 (CRMP-2) is a mammalian homologue of UNC-33, mutations in which result in abnormal axon termination. We recently demonstrated that CRMP-2 is critical for axonal differentiation. Here, we identify two activities of CRMP-2: tubulin-heterodimer binding and the promotion of microtubule assembly. ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| DPYSL2 TUBB3 | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | Low | - | BioGRID | - | |
| TUBB3 DPYSL2 | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - |
Curated By
- BioGRID