BAIT
MARCH1
MARCH-I, RNF171
membrane-associated ring finger (C3HC4) 1, E3 ubiquitin protein ligase
GO Process (3)
GO Function (2)
GO Component (8)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
HLA-DRB1
DRB1, DRw10, HLA-DR1B, HLA-DRB, SS1, XXbac-BPG161M6.1
major histocompatibility complex, class II, DR beta 1
GO Process (19)
GO Function (3)
GO Component (16)
Gene Ontology Biological Process
- T cell costimulation [TAS]
- T cell receptor signaling pathway [TAS]
- T-helper 1 type immune response [ISS]
- antigen processing and presentation of exogenous peptide antigen via MHC class II [TAS]
- cytokine-mediated signaling pathway [TAS]
- detection of bacterium [ISS]
- humoral immune response mediated by circulating immunoglobulin [IDA, ISS]
- immune response [ISS, NAS]
- immunoglobulin production involved in immunoglobulin mediated immune response [IDA, ISS]
- inflammatory response to antigenic stimulus [ISS]
- interferon-gamma-mediated signaling pathway [TAS]
- negative regulation of T cell proliferation [ISS]
- negative regulation of interferon-gamma production [ISS]
- peptide antigen assembly with MHC class II protein complex [IDA]
- polysaccharide assembly with MHC class II protein complex [IDA]
- positive regulation of insulin secretion involved in cellular response to glucose stimulus [ISS]
- protein tetramerization [ISS]
- regulation of interleukin-10 secretion [ISS]
- regulation of interleukin-4 production [ISS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- ER to Golgi transport vesicle membrane [TAS]
- Golgi membrane [TAS]
- MHC class II protein complex [IDA, ISS]
- cell surface [IDA]
- clathrin-coated endocytic vesicle membrane [TAS]
- endocytic vesicle membrane [TAS]
- external side of plasma membrane [ISS]
- extracellular vesicular exosome [IDA]
- integral component of lumenal side of endoplasmic reticulum membrane [TAS]
- integral component of plasma membrane [TAS]
- late endosome membrane [IDA]
- lysosomal membrane [IDA, TAS]
- membrane [IDA, NAS]
- plasma membrane [TAS]
- trans-Golgi network membrane [TAS]
- transport vesicle membrane [TAS]
Homo sapiens
FRET
An interaction is inferred when close proximity of interaction partners is detected by fluorescence resonance energy transfer between pairs of fluorophore-labeled molecules, such as occurs between CFP (donor) and YFP (acceptor) fusion proteins.
Publication
Identification of a novel motif that affects the conformation and activity of the MARCH1 E3 ubiquitin ligase.
MARCH1, a member of the membrane-associated RING-CH family of E3 ubiquitin ligases, regulates antigen presentation by down-regulating the cell surface expression of MHC class II and CD86 molecules. MARCH1 is a transmembrane protein that exposes both its N- and C-terminus to the cytoplasm. Here, we have conducted a structure-function analysis of its two cytoplasmic tails to gain insights into the ... [more]
J. Cell. Sci. Dec. 21, 2012; 0(0); [Pubmed: 23264739]
Throughput
- Low Throughput
Curated By
- BioGRID